V.A. Mikhalev, B.Ya. Syropyatov, A.I. Mikhalev, M.I. Vakhrin

According to the literature in the reaction of N-acetylisatin with alkylamines substituted amides of N-acetylisatinic acids are formed, but there are no data about biological activity of obtained substances. In the course of the experiments we have found that in analogical conditions by heating of N-acetylisatin with alkyl- or arylamines corresponding substituted amides of N-acetylisatinic asid are obtained in high yields. 11 new compounds have been obtained and their structure was confirmed with TLC, IR- and NMR H1 - spectroscopy. Biological tests showed that some of obtained amides of N-acetylisatinic acid have analgesic activity comparable to activity of metamizole sodium (analgin). The influence of compounds on blood coagulation system in compare with standard preparations of heparine and etamzilate have been studied. The search for new biologically active compounds in the rates of amides of N-acetylisatinic acids is very perspective.