350 rub
Journal №11 for 2012 г.
Article in number:
Lipid Exchange in Rats Obtaining Excessive Doses of Iron and Copper Salts with Drinking Water
Keywords: iron copper dyslipoproteinemia obesity
Authors:
A.A. Tinkov, A.V. Skalny, A.A. Nikonorov
Abstract:
In the current experiment on female Wistar rats the influence of inorganic salts of Fe and Cu on the serum lipid profile and weight gain was studied. It is shown that chronic consumption of drinking water containing iron and copper if doses exceeding maximum permissible concentration 2 and 4-fold lead to dose-dependent cumulation of metals in rats - hair. The combined intake of iron and copper resulted in potentiation in cumulative effect. Chronic intake of Fe2+ and Cu2+ affected food behavior leading to increased daily food consumption by 10-12 % in comparison to controls and was accompanied with weight gain. The more expressed changes in lipid profile were hypercholesterolaemia and hypertriacylglycerolaemia in groups of animals receiving maximal concentrations of iron and copper and were characterized by 23 and 17 % increase in comparison to baseline. At the same time animals obtaining 4,88; 9,76 mg/l of copper and a combination of iron and copper with drinking water had a hyper-β-lipoproteinaemia that exceeded contron values by 50, 130 and 65 % respectively. It is concluded that chronic consumption of iron and copper salts enhances the possibility of excessive weight and atherogenic dyslipoproteinaemias development.
Pages: 58-62
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