350 rub
Journal №11 for 2012 г.
Article in number:
Anti-Dna Antibodies: Focus on Polyspecificity
Keywords: аnti-DNA antibodies polyspecificity cross-reactivity autoimmune diseases
Authors:
A.Yu. Khramova, R.I. Zhdanov
Abstract:
Antibodies (Аbs), produced by immune system, are macromolecules directed to neutralize allogenic and modified internal antigens (AG). The rising titre of Abs with somatic mutations, which leads to changes in affinity and avidity-pathological Abs (usually IgG) is a typical pathological hallmark. Anti-DNA Abs with DNA-hydrolyzing activity are the metal-dependent endonucleases. There are no spiral structural motives in their structure; therefore Anti-DNA Abs may bind with specifically located phosphate residues of a AG molecule. Some Abs, including Anti-DNA Abs possess the characteristic of polyreactivity (cross-reactivity) ? a possibility to make a low-affinity and dose-dependent binding with several endogenous or exogenous AGs with structural similarity. Interaction with a wide range of AGs and maintaining of lymphocytes - survival rate without AG stimuli can be noted as positive sides of the given phenomenon. However, cross-reactivity can have some unfavorable consequences. First of all, cross-reactions between Anti-DNA Abs and other tissue and cellular AG structures can lead to their additional damage. On the other hand, pathological changes in cellular functions and apoptosis are the result of Anti-DNA Abs penetration, which leads to the releasing of apoptotic material-a trigger for additional Anti-DNA Abs synthesis and to development of different pathological effects.
Pages: 32-38
References
  1. Gupta S. Antibodies: Basic Mechanisms and Emerging Concepts // J. Clin. Immunol. 2010. № 30. P. 1-3.
  2. Almqvist N., Winkler T., Mårtensson I.-L. Autoantibodies: Focus on anti-DNA antibodies // Self Nonself. 2011. №2(1). P. 11-18.
  3. Furukawa F., Kashihara M., Imamura S., Ohshio G., Hamashima Y. Evaluation of anti-cardiolipin antibody and its cross-reactivity in sera of patients with lepromatous leprosy // Archives of Dermatological Research. 1986. № 278(4). P. 317-319.
  4. Rauch J., Tannenbaum H., Stollar B., Schwartz R.Monoclonal anti-cardiolipin antibodies bind to DNA // Eur. J. Immunol. 1984. №14(6). P. 529-534.
  5. Thrasyvoulides A., Lymberdi P. Antibodies cross-reacting with thyroglobulin and thyroid peroxidase are induced by immunization of rabbits with an immunogenic thyroglibulin 20mer pepide // Clin. Exp. Immunol. 2004. № 138. P. 423-429.
  6. Shütt C., Bröker B. Grundwissen Immunologie. München: Elsevier. 2006. P. 7-8.
  7. Hilvert D. Critical Analysis of Antibody Catalysis // Annu. Rev. Biochem. 2000. № 69. P. 751-793.
  8. Gabibov A., Ponomarenko N., Tretyak E., Paltsev M., Suchkov S. Catalytic autoantibodies in clinical autoimmunity and modern medicine // Autoimmun. Rev. 2006. № 5(5). P. 324-330.
  9. George J., Shoenfeld Y. Natural autoantibodies / Autoantibodies, edited by J. Peter and Y. Shoenfeld. Amsterdam: Elsevier. 1996. P. 534-539.
  10. Elkon K., Casali P. Nature and functions of autoantibodies // Nat. Clin. Pract. Rheumatol. 2008. № 4(9). P. 491-498.
  11. Pavlovic M., Cavallo M., Kats A., Kotlarchyk A., Zhuang H., Shoenfeld Y.From Pauling's abzyme concept to the new era of hydrolytic anti-DNA autoantibodies: a link to rational vaccine design - // Int. J. Bioinform. Res. Appl. 2011. № 7 (3). Р. 220-238.
  12. Khan S., Alam R., Ali M., Ali A. Oxygen free radical modified DNA: implications in the etiopathogenesis of systemic lupus erythematosus // Indian Journal of Clinical Biochemistry. 2009. № 24. P. 123-130.
  13. Narayanan A., Sellers B., Jacobson M.Energy-based analysis and prediction of the orientation between light- and heavy-chain antibody variable domains // J. Mol. Biol. 2009. № 388 (5). P. 941-953.
  14. Jang Y., Stollar B. Anti- DNA antibodies: aspects of structure and pathogenicity // Cell. Mol. Life Sci. 2003. № 60(2). P. 309-320.
  15. Leskovek N., Mackay I., Rose N. Cell Damage and Autoimmunity: A Critical Appraisal // Journal of Autoimmunity. 2008. № 30(1-2). P. 5-11.
  16. Hiepe F., Dörner T. Autoantikörper und die Zellen, die sie machen // Z. Rheumatol. 2005. № 64(6). P. 389-395.
  17. Prothero K., Stahl J., Carrel L. Dosage compensation and gene expression on the mammalian X chromosome: one plus one does not always equal two // Chromosome Research. 2009. № 17(5). P. 637-648.
  18. von Gunten S., Simon H.-U. Cell Death Modulation by Intravenous Immunoglobulin // J. Clin. Immunol. 2010. № 30. P. 24-30.
  19. Nevzorova T., Vinter V., Konovalova O., Salakhov M.Mechanism of action of DNA-hydrolyzing antibodies to DNA from blood of patients with systemic lupus erythematosus // Biochemistry (Mosc). 2006. № 71 (11). P. 1238-1246.
  20. Kozyr A., Kolesnikov A., Zelenova N., Sashchenko L., Mikhalap S., Bulina M., Ignatova A., Favorov P., Gabibov A. Autoantibodies to nuclear antigens: correlation between cytotoxicity and DNA-hydrolyzing activity  // Appl. Biochem. Biotechnol. 2000. № 83 (1-3). P. 297-313.
  21. Kozyr A., Sashchenko L., Kolesnikov A., Zelenova N., Khaidukov S., Ignatova A., Bobik T., Gabibov A., Alekberova Z., Suchkov S., Gnuchev N. Anti-DNA autoantibodies reveal toxicity to tumor cell lines // Immunol. Lett. 2002. № 80 (1). P. 41-47.
  22. An W. Histone acetilation and methilation: combinatorial players for transcriptional regulation // Subcellular Biochemistry. 2007. № 41. Part III. P. 355-374.
  23. Runge M. Principles of Molecular Medicine, Second Edition / edited by: M. Runge, C. Patterson. New Jersey: Humana Press. 2006. P. 970-978.
  24. Alarcón-Segovia D., Llorente L., Ruíz-Argüelles A. The Penetration of Autoantibodies into Cells May Induce Tolerance to Self by Apoptosis of Autoreactive Lymphocytes and Cause Autoimmune Disease by Dysregulation and/or Cell Damage // Journal of Autoimmunity. 1996. № 9. P. 295-300.
  25. Alarcón-Segovia D., Llorente L., Ruíz-Argüelles A. Autoantibodies that penetrate into living cells / Autoantibodies, edited by J. Peter and Y. Shoenfeld. Amsterdam: Elsevier. 1996. P. 227-236.
  26. Ternynck T., Avrameas A., Ragimbeau J., Buttin G., Avrameas S. Immunochemical, Structural and Translocating Properties of Anti-DNA Antibodies from (NZB×NZW)F1 Mice// J. Autoimmun. 1998. № 11(5). P. 511-521.
  27. Kozyr A., Gabibov A. DNA-hydrolyzing Ab: is catalytic activity a clue for physiological significance - // Autoimmunity. 2009. № 42 (4). P. 359-361.
  28. Vlahakos D., Foster M., Ucci A., Barrett K., Datta S., Madaio M.Murine monoclonal anti-DNA antibodies penetrate cells, bind to nuclei, and induce glomerular proliferation and proteinuria in vivo // J. Am. Soc. Nephrol. 1992. № 2(8). P. 1345-1354.
  29. Ruíz-Argüelles A., Pérez-romano B., Llorente L., Alarcón-Segovia D., Castellanos J. Penetration of anti-DNA antibodies into immature live cells // Journal of Autoimmunity. 1998. № 11(5). P. 547-556.
  30. Ruiz-Argüelles A., Brito G., Reyes-Izquierdo P., Pérez-Romano B., Sánchez-Sosa S.Apoptosis of melanocytes in vitiligo results from antibody penetration // J. Autoimmun.2007. № 29(4). P. 281-286.
  31. Mannik M., Person R. Deep penetration of antibodies into the articular cartilage of patients with rheumatoid arthritis // Rheumatol. Int. 1994. № 14(3). P. 95-102.
  32. Rice J., Kowal C., Volpe B., DeGiorgio L., Diamond B. Molecular mimicry: anti-DNA antibodies bind microbial and nonnucleic acid self-antigens // Curr. Top. Microbiol. Immunol. 2005. № 296. P. 137-151.
  33. Zhou Z., Tzioufas A., Notkins A. Properties and Function of Polyreactive Antibodies and Polyreactive Antigen - Binding B Cells // J. Autoimmun. 2007. № 29(4). P. 219-228.
  34. Banks T., Babakhani F., Poulos B., Duffy J., Kibler R. Characterization of cross ? reactive anti - DNA autoantibodies in murine lupus // Immunol. Invest. 1993. № 22(3). P. 229-248.
  35. Hurez V., Dietrich G., Kaveri S., Kazatchkine M.Polyreactivity is a property of natural and disease-associated human autoantibodies // Scand. J. Immunol. 1996. № 38 (2). P. 190-196.
  36. Isenberg D., Manson J., Ehrenstein M., Rahman A. Fifty years of anti - dsDNA antibodies: are we approaching journey-s end - // Rheumatology. 2007. № 46(7). P. 1052-1056.
  37. Pavlovic M., Kats A., Cavallo M., Chen R., Hartmann J., Shoenfeld Y. Pathogenic and Epiphenomenal Anti-DNA Antibodies in SLE // Autoimmune Dis. 2010. № 20. P. 462841.
  38. Oki M., Aihara H., Ito T. Role of of histone phosphorilation in chromatin dynamics and its implications in diseases // Subcellular Biochemistry. 2007. № 41. Part III. P. 323-340.
  39. Munoz L., van Bavel C., Franz S., Berden J., Herrmann M., van der Vlag J. Apoptosis in the pathogenesis of systemic lupus erythematosus // Lupus. 2008. №17(5). P. 371-375.
  40. Pankewycz O., Migliorini P., Madaio M. Polyreactive autoantibodies are nephritogenic in murine lupus nephritis // J. Immunol. 1987. № 139(10). P. 3287-3294.
  41. Liang Z., Xie C., Chen C., Kreska D., Hsu K., Li L., Zhou X., Mohan C. Pathogenic Profiles and Molecular Signatures of Antinuclear Autoantibodies Rescued from NZM2410 Lupus Mice // Exp. Med. 2004. № 199(3). P. 381-398.
  42. Rubin R., Bell S., Burlingame R. Autoantibodies associated with lupus induced by diverse drugs target a similar epitope in the (H2A-H2B)-DNA complex // J. Clin. Invest. 1992. № 90 (1). P. 165-173.
  43. Mjelle J.E., Rekvig O.P., Fenton K.A. Nucleosomes possess a high affinity for glomerular laminin and соllagen IV and bind nephritogenic antibodies in murine lupus - like nephritis // Ann. Rheum. Dis. 2007. № 66(12). Р. 1661-1668.
  44. Struchkov V., Strazhevskaya N., Zhdanov R. DNA-bound lipids of normal and tumor cells: retrospective and outlooks for functional genomics // Bioelectrochemistry. 2002. № 58(1). P. 23-30.
  45. Zhao Z., Weinstein E., Tuzova M., Davidson A., Mundel P., Marambio P., Putterman C. Cross-reactivity of human lupus anti-DNAantibodies with alpha-actinin and nephritogenic potential // Arthritis Rheum. 2005. № 52(2). P. 522-530.
  46. Raz E., Brezis M., Rosenmann E., Eilat D.Anti - DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney // J. Immunol.1989. № 142(9). P. 3076-3082.
  47. Deocharan B., Qing X., Beger F., Putterman C.Antigenic triggers and molecular targets for anti - double - stranded DNA antibodies // Lupus. 2002. № 11(12). P. 865-871.
  48. Faaber P., Rijke T., van de Putte L., Capel P., Berden J. Cross - reactivity of Human and Murine Anti - DNA Antibodies with Heparin Sulfate // J. Clin. Invest. 1986. № 77(6). P. 1824-1830.
  49. Struchkov V., Strazhevskaya N., Zhdanov R. DNA - bound lipids of normal and tumor cells: retrospective and outlooks for functional genomics // Bioelectrochemistry. 2002. № 58(1). P. 23-30.
  50. Eilat D., Zlotnick Y., Fischel R. Evaluation of the cross - reation between anti- DNA and anti- cardiolipin antibodies in SLE and experimental animals // Clin. Exp. Immunol. № 65(2). P. 269-278.
  51. Zhdanov R.I., Struchkov V.A., Dyabina O.S., Strazhevskaya N.B. Chromatin-bound cardiolipin - phospholipid of proliferation // Cytobios. 2001. № 106(411). P. 55-61.
  52. Carroll P., Stafford D., Schwartz R., Stollar B.Murine monoclonal anti - DNA autoantibodies bind to endogenous bacteria // J. Immunol. 1985. № 135(2). P. 1086-1090.
  53. Puccetti A., Madaio M., Bellese G., Migliorini P. Anti-DNA Antibodies Bind to DNase I // J. Exp. Med. 2005. № 181. P. 1797-1804.
  54. DeGiorgio L., Konstantinov K., Lee S., Hardin J., Volpe B., Diamond B. A subset of lupus anti-DNA antibodies cross - reacts with the NR2 glutamate receptor in systemic lupus erythematosus // Nat. Med. 2001. № 7(11). P. 1189-1193.
  55. Kotzin B., Kozora E. Anti-DNA meets NMDA in neuropsychiatric lupus // Nat. Med. 2001. № 7 (11). P. 1175-1176.
  56. Sun K., Liu W., Tsai C., Tang S., Han S., Yu C. Anti-dsDNA antibodies cross - react with ribosomal P proteins expressed on the surface of glomerular mesangial cells to exert a cytostatic effect // Immunology. 1995. № 85 (2). P. 262-269.
  57. Tsuzaka K., Leu A., Frank M., Movafagh B., Koscec M.,
    Winkler T., Kalden J., Reichlin M.    Lupus autoantibodies to double-stranded DNA cross-react with ribosomal protein S1 // J. Immunol. 1996. № 156(4). P. 1668-1675.
  58. Alberdi F., Dadone J., Ryazanov A., Isenberg D., Ravirajan C., Reichlin M.Cross - reaction of lupus anti - dsDNA antibodies with protein translation factor EF-2 // Clin. Immunol. 2001. № 98(2). P. 293-300.
  59. Zhang J., Jacobi A., Wang T., Berlin R., Volpe B., Diamond B. Polyreactive autoantibodies in systemic lupus erythematosus have pathogenic potential // J. Autoimmun. 2009. № 33(3-4). P. 270-274.
  60. Reimer G., Rubin R., Kotzin B., Tan E.Anti - native DNA antibodies from autoimmune sera also bind to DNA in mitochondria // J. Immunol. 1984. № 133(5). P. 2532-2536.
  61. Triolo G., Palumbo A., Giardina E., Davi G., Triolo G. Anti platelet property of anti - single - stranded DNA antibodies in type 1 (insulin - dependent) diabetes mellitus // Diabetes Res. 1994. № 26(2). P. 79-87.