V.F. Okhotnikova, T.V. Kachalina, M.V. Balakina, D.S. Kachalin, O.A. Semkina, N.Y. Ottс, K.M. Sakanyan

Plants for making of new effective drugs were investigated in All-Russian Institute of Medicinal and Aromatic Plants. Each new drug for medicinal using must have good medicinal effect, must have advantages over widely known drugs, haven´t harmful effect on human organism. Most of hard medicinal forms are contain high amount of excepients. These components are add necessary technological properties for tablet mass. Excepients must assure the therapeutic effect at minimum dose of drug. The method of direct pressing is most economic method using for production of hard medicinal forms. In this case, lactose 80 Mesh, microcrystalline cellulose (MCC) types of (Vivapur-12, Vivapur-102, Vivapur-200) and other widely used. Combined ingredients are added to tablet mass for method of direct pressing with goal of optimization of drug composition. Polymer Na-carboxymethylcellulose was used at investigation of sublingval tablets of prolong effect with dry extract of hyporamin. Polymer was used on stady of mixing of components and also added in mass before granulation. Starch as excepient was used at production of estiphan tablets for prevention of caramelisation. Tablets of estiphan was produced by method of pressing with using lactose, methylcellulose. Sibectan is original complex drug. Method of adding the sum of biological active compounds to tabletic mass type by type was used for production of this preparation. The excepient component for sibectan tablets is aerosol. The using MCC and explosol at investigation of granules with dry extracts are prefer. Addition of MCC are increase durability and decrease the amount of excepients. Explosol are assure the good disintegration of granules. Sparkling tablets is one of modern pharmaceutical forms. The preparation with polysaccharides from Malva sylvestris herb has been devised in institute. The excepients of this preparation are lactopress, polyvinylpyrrolidone, emdex, MCC-90, citric acid, sodium hydrocarbonate. Method of direct pressing was used for production of tablets with extract of Malva sylvestris herb. By method of direct pressing the sparkling tablets of lutenurin (with optimal dose equal 0.003 g) was investigated. Also tablets with dry extract of Comarum palustre was investigated. Aerosol-380, collidonium, MCC, explosol, calcium stearate were used as excepients for production of tablets.