T.V. Tikhonova, E.B. Yakubova, K.I. Kienskaya

The pressing questions of production of the effective transdermal delivery systems for microelements are considered at the article «The dependency of physicochemical properties of microemulsion systems based on nonionic surfactants from metal ions different valency». This article is focusing on generalization of the data of the physical and chemical analysis of microemulsion compositions based on nonionic glycerin and fat acids derivatives. The influence of various ions of metals Zn2+, Mn2+, Ca2+, Fe3+, Na+ on transport characteristics of microemulsions (viscosity, electrical conductivity, temperature of turbidity) is considered in this work.. The article shares on 4 parts. In the "introduction" the general characteristic of a problem reflecting an urgency of work is given, the purpose and research problems is formulated. Further, in head «materials and methods» the characteristic of objects of research is given and techniques of experiments are described. In the basic part the author results a number of the diagrams displaying the electrical conductivity, viscosity, temperature of turbidity of microemulsions as a function of a volume of water phase concluded of metal ions by different valency. The author does the conclusion that the most stable compositions with a wide concentration range are received during emulsifying of water solutions of salts of bivalent metals (Zn2+, Mn2+, Ca2+). The basic value of work is an exhaustive consideration of influence of thermodynamic parameters: temperatures, a volume fraction of a disperse phase, and also the chemical nature of components at the phase surface on structural changes in microemulsions. From the practical point of view the generalization of the received results to the phase diagrams of systems water/surfactants/oil which can be a basis at the preparation of microemulsion compositions.