350 rub
Journal №5 for 2011 г.
Article in number:
Polymorphism of Endothelin-1 Gene Lys198Asn Locus and its Protein Product Blood Level at Hemorrhagic Fever with Renal Syndrome
Keywords: endothelin-1 polymorphism of endothelin-1 gene Lys198Asn locus hemorrhagic fever with renal syndrome
Authors:
A.A. Baygildina, D.V. Islamgulov, E.K. Khusnutdinova
Abstract:
The research aimed to explore polymorphism of the endothelin-1 gene Lys198Asn locus as disease predictor and changes of endothelin-1(ET-1) blood plasma level at hemorrhagic fever with renal syndrome (HFRS). In examination 363 patients at the age of 22 - 65 were involved. Blood genomic DNA was isolated by phenol-chloroformic extraction, genetic locuses were researched by polymerase chain reaction. ET-1 blood level was determined with Biomedica Group (Austria) assay kit. There were no statistically significant differences in ET-1 gene Lys198Asn locus alleles and genotypes frequencies between HFRS patients groups and control. We revealed that ET-1 blood level is statistically significant decreased at all periods of HFRS with different severity and the lowest level at complicated form of disease was observed. We made a conclusion that low ET-1 blood level at HFRS is not genetically determined and represents an adequate metabolic response of an organism on endotheliotropic virus action.
Pages: 59-63
References
  1. Бувальцев В.И. Дисфункция эндотелия как новая концепция профилактики и лечения сердечно-сосудистых заболеваний // Междунар. мед. журн. 2001. № 3. С. 202-208.
  2. Галиева А.Т. Патогенетическое значение оксида азота при геморрагической лихорадке с почечным синдромом. Автореф. дисс-канд. мед. наук. Уфа. 2004. 26 с.
  3. Минушкина Л.О., Игнатьев И.В., Бражник В.А., Затейщиков Д.А., Носиков В.В., Сидоренко Б.А. Полиморфные маркеры генов EDN1, PPARG2 и MTHFR ассоциированы с тяжелым течением артериальной гипертонии // Тезисы Российского национального конгресса кардиологов «От исследований к стандартам лечения». М. 2003. С. 215.
  4. Сиротин Б.З. Геморрагическая лихорадка с почечным синдромом. Хабаровск. 1994. 300 с.
  5. Alonso D., Radomski M.W. The nitric oxide - endothelin-1 connection // Heart Fail. Rev. 2003. V. 8. P. 107-118.
  6. Barden A.E., Herbison C.E., Beilin L.J., Michael C.A., Walters B.N., Van Bockxmeer F.M. Association between the endothelin-1 gene Lys198Asn polymorphism blood pressure and plasma endothelin-1 levels in normal and pre-eclamptic pregnancy // J Hypertens. 2001. V. 19. P. 1775-1782.
  7. Boulanger C., Luscher T.F. Release of endothelin from porcine aorta. Inhibition by endothelium derived nitric oxide // J. Clin. Invest. 1990. V. 85. P. 587-590.
  8. Cardillo C., Kilcoyne C.M., Cannon R.O., Panza J.A. Increased activity of endogenous endothelin in patients with hypercholesterolemia // J. Am. Coll. Cardiol. 2000. V. 36. № 5. P. 1483-1488.
  9. Galie N., Manes A., Branzi A. The endothelin system in pulmonary arterial hypertension // Cardiovasc. Res. 2004. V. 61. P. 227-237.
  10. Haynes W.G., Webb D. Endothelin as a regulator of cardiovascular function in health and disease // Hypertens. 1988. V. 16. P. 1081-1098.
  11. Hirata Y., Emori T., Kanno K., Imai T., Ohta K., Marumo F. Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells // Clin. Invest. 1993. V. 91. P. 1367-1373.
  12. Kodama M., Kanaide H., Abe S., Hirano K., Nakamura M. Endothelin-induced Ca-independent contraction of the porcine coronary artery // Biochem.Biophys.Res Commun. 1989. V. 160. P. 1302-1308.
  13. Luscher T.F., Barton M. Endothelin and endothelin receptors antagonists: therapeutic considerations for a novel class of cardiovascular drugs // Circulation. 2000. V. 102. P. 2434-2440.
  14. Treiber F., Barbeau P., Harshfield G. Endothelin-1 gene lys198asn polymorphism and blood pressure reactivity // Hypertension. 2003. V. 42. P. 494-499.
  15. Widlansky M.E., Gokce N., Keaney J.F., Vita J.A. The clinical implications of endothelial dysfunction // J. Am. Coll. Cardiol. 2003. V. 42. P. 1149-1160.
  16. Yanagisawa M., Kurihara H., Kimura S., Tomobe Y., Kobayashi M., Mitsui Y., Yazaki Y., Goto K., Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells // Nature. 1988. V. 332. P. 411-415.
  17. Yang Z., Ming X.F. Recent advances in understanding endothelial dysfunction in atherosclerosis // Clin. Med. Res. 2006. V. 1. P. 53-65.