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Journal №4 for 2011 г.
Article in number:
Endothelin-converting enzyme inhibitor promotes renovascular hypertension development in rats (1 kidney-1 clip Goldblatt model)
Keywords: endothelin-1 endothelin-converting enzyme inhibitor renovascular hypertension 1 kidney-1 clip Goldblatt model renal physiology
Authors:
M.E. Ilatovskaya, S.I. Sofronova, V.F. Pozdnev, N.A. Medvedeva
Abstract:
The study was aimed to determine the effect of chronic inhibition of endothelin-1 synthesis on renovascular hypertension development. Male Wistar rats were subjected to an operation, according to the «1 kidney, 1 сlip» method and were administered to an original endothelin-converting enzyme inhibitor PP36 per os with drinking water in an amount of 2,3 mg/kg per day for 4 weeks. Significant reduction of circulating endothelin-1 after chronic PP36 administration was obtained only in normotensive, but not hypertensive rats. The data obtained indicates that chronic inhibition of endothelin-1 synthesis results in more manifested renovascular hypertension. We speculate that it might be a result of endothelin-1 downregulation in the kidney. It is suggested that chronic inhibition of endothelin-1 synthesis in the kidney might lead to reduced excretory function resulting in water and salt retention.
Pages: 23-29
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