350 rub
Journal №12 for 2011 г.
Article in number:
The Role of Factors of Angiogenesis in Patients with Neuroendocrine Tumors of Gastrointestinal Tract and Pancreass
Keywords: vascular endothelial growth factor (VEGF) endostatin tumor necrosis factor (TNF-&#946 ) neuroendocrine tumor
Authors:
S.B. Polikarpova, N.V. Lyubimova, A.S. Ogerelev, N.I. Borovskaya, A.T.Kokolishvili
Abstract:
We compared serum vascular endothelial growth factor (VEGF), endostatin and tumor necrosis factor (TNF-β) levels in 20 patients with neuroendocrine tumors and 25 practically normal donors (control group). Mean serum VEGF, endostatin and TNF-β concentrations in neuroendocrine tumors cases were not significantly different from control. There was no relationship between VEGF, endostatin and TNF-β levels and patients, gender and age. Patients with malignant neuroendocrine tumors presented relationship between serum endostatin and TNF-β levels and tumors size. Cases with benign neuroendocrine tumors demonstrated a significant positive correlation between serum VEGF and endostatin levels, but an inverse relationship between serum VEGF and TNF-β levels. High levels of serum endostatin and (>100 ng/ml) low levels TNF-β (<30 pg/ml) may predict worse disease free survival. Longer follow-up is needed for assessment of effect on survival.
Pages: 50-54
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