A.S. Kedik, I.E. Yartsev, A.O. Bocharova, V.I. Sakaeva

The effect of substances such as taurine, vinylpyrrolidone/vinylpyridine copolymer and Taurine/copolymer complex in mice experiments at 40 and 200 mg/kg doses on humoral and cellular immunity and phagocytosis studied. The substances effect on humoral immunity was assessed by the Jerne reaction (antibody-forming cell). To estimate the substances effect on the T-cell component of immune system the method of reaction «Graft-versus-host disease» (GVHD) in the regional lymph nodes used. Estimation of peritoneal macrophages phagocytic activity was determined by the absorption intensity or the dye. As a result of research conducted on mice, there was found that a complex vinylpyrrolidone/vinylpyridine copolymer and taurine possesses of the immunostimulatory effect on humoral and cellular immunity reactions. The vinylpyrrolidone/vinylpyridine copolymer increases the macrophages phagocytic activity, whereas when applying a taurine and its combination with a polymer such action was not revealed.