C.V. Arkhipova, N.A. Zorin, M.U. Yankin, V.M. Podkhomutnikov, V.N. Zorina, T.G. Ryabicheva

Peculiarities of cytokine regulation of negative and positive acute phase proteins at micro- and macrofocal form of myocardial infarction for deciding their role in pathogenesis of disease were shown. There were studied the serum levels of tumor necrosis factor?α and interleukins (IL-1β, 6, 8, 18), receptor antagonist interleukin - 1β (RAIL-1β), lactoferrin (LF), α2-macroglobulin (MG), plasmin (PL) and concentrations of circulating MG-PL complexes among 36 men (57,2±9,6 years old) with micro- and macrofocal form of MI on 1st , 7th and 14th days from the start of the disease. We have shown that microfocal form of MI was accompanied by the increase of some proinflammatory cytokines concentrations (IL-1β, TNF-α), conforming with decreasing levels of such negative acute phase proteins as MG and PL at the beginning of disease, with delayed increase of IL-8 and LF concentrations till the end of the second week. By macrofocal form of MI the IL-1β, MG and PL concentrations remain unchangeable, but IL-6, TNF, RAIL-1β, L-8 levels increased within the first day of the disease, as well as the concentration of such positive acute phase protein as LF, being a sensitive marker of the width of the inflammatory damage. We suggest that showed differences can be used as additional markers at differential diagnostics of MI forms, particularly when conventional ECG readings are not informative.