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Diagnostics of diseases by pattern of self-organization in drying drops of biological fluids


N.A. Shvetsova

Modeling of processes of self-organization in drying drops of biological fluids is a cardinally new approach to research of biological substrates including blood plasma, blood serum, saliva and eyewater. The research aimed at modeling of processes of structuring of drops of biological fluids solves the fundamental scientific problem of finding connection between pathological processes going by in an organism, changes in physical and physicochemical properties of biological fluids caused by these processes and the type of structures that can be observed in a dried out drop if biological fluid. For the first time the effect of dehydration self-organization of biological fluids was discovered more than 20 years ago by ophthalmologist E.Rapis. Nowadays the effect of dehydration self-organization of biological fluids is the basis of one of the methods of medical diagnostics – the method of wedge-like dehydration, worked out by V.Shabalin and S.Shatokhina. In a brief description the essence of the method is as follows. A drop of a biological fluid is applied at the object-plate and then it is being dried out at the conditions suitable for each single case. After that the phase is being photographed with a microscope of a digital camera at microfilming mode. Then there should be held qualitative and quantitive assessments of the morphological elements of the phase. Quantitive data are counted with the help of computer programs. The main task of this sort of research id to interpret the image, to single out classification featured and to compare the structured observed in the image of the dried out drop of biological fluid with the disease and its stage. The process of dehydration self-organization of biological fluids have been compared with analogous processes going by during drying of colloidal solutions. It has been proven that these processes can be observed within the framework of standard approaches to analysis of fluids of non-organic origin. More over there was suggested a model describing the influence of the process of spatial redistribution of components of biological fluids in the method of wedge-like dehydration which significantly simplifies understanding of what’s happening. The results of this type of research can be rather useful as the obtained algorithms help to automotize the process of the phase analysis and significantly simplify the work of medical personnel. Further development in this direction will help to analyze automatically the pictures of different medico-biological fluids.
June 24, 2020
May 29, 2020

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