artificial and auxiliary blood circulation
V.I. Shumakov, A.A. Lubyako, I.S. Kurapeev, Yu.G. Matveyev, V.S. Suskova,
V.I. Emetz, A.V. Pimenov, O.S. Gaydova
It is known that the prolonged work of the apparatuses for artificial and auxiliary blood circulation with the fulfillment of complex operations on the “open heart” disoriented practically all natural mechanisms of the neurohumoral regulation of basic exchange of substances, suppressing thus the protective-physiological functions of organism. This is connected with the mechanical injury of the blood and, as a result, with the metabolic injury of vitality important organs, up to the development of the organ and polyorgans insufficiency. This requires from company-producers to use protective coatings for the perfusion systems, to let out the special filters, which make it possible to move away the activated leukocytes from the circulation.
It is shown on 364 cardiosurgery patients, that the start in the outline of the apparatus for the artificial blood circulation of the shear of fresh xenogenous spleen makes it possible in 2-2,9 times to decrease the unbalance of exchange of substances, caused by the injury, applied to organism by the apparatuses of artificial and auxiliary blood circulation. Effect is connected with the immune protective properties of biomaterial, provide ford with its endocrine activity.
Also, it is shown, which the shielding properties of intra-operating splenoperfusion so stimulates pro-tective-physiological reactions, that the organism of patient itself in the state will manage this heavy pathology as bacterial endocardites by 5-17% to decrease the frequency of postoperative purulent and pyoseptic complications in 6-14 times to decrease of the hospital lethality, if such complications appear.
As the results of the tests of the contemporary biocompatible perfusion coatings of perfusion systems from the chief firm-producers of Italy, USA, Japan and Germany showed, their application only insignificantly changes the nature of damages, but it frees patient not from their presence, not from their depth.