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The effect of nanoparticles chromium and chromium picolinate on hematological parameters of blood in laboratory animals

DOI 10.18127/j20700997-201804-07

Keywords:

S.V. Lebedev - Dr.Sc. (Biol.), Professor, Leading Research Scientist, Department of Biotechnology of Animal Raw Materials and Aquaculture, Federal Research Center for Biological Systems and Agrotechnologies
of the Russian Academy of Sciences Department (Orenburg)
I.A. Gavrish - Junior Research Scientist, Laboratory of Biological Trials and Expertise, Federal Research Center for Biological Systems and Agrotechnologies of the Russian Academy of Sciences (Orenburg)
E-mail: gavrish.irina.ogu@gmail.com
O.V. Kvan – Ph.D. (Biol.), Research Scientist, Institute of Bioelementology, Orenburg State University, Federal State Scientific Institution of Federal Scientific Center of Biological Systems and Agrotechnologies of the Russian Academy of Sciences (Orenburg)
E-mail: kwan111@yandex.ru
E.A. Rusakova - Ph.D. (Biol.), Research Scientist, Institute of Bioelementology, Orenburg State University;  Federal Research Center for Biological Systems and Agrotechnologies of the Russian Academy of Sciences (Orenburg)
E-mail: elenka_rs@mail.ru
I.Z. Gubaidullina - Junior Research Scientist, Laboratory of Biological Trials and Expertise, Federal State Scientific Institution of Federal Scientific Center of Biological Systems and Agrotechnologies of the Russian Academy of Sciences (Orenburg)
E-mail: gubaidullinae@mail.ru


Chromium is a necessary element for the metabolism of fats, proteins and carbohydrates in humans and animals, it is in-volved in the signal cascade to increase insulin activity (Evans G.W., 1992, Lien T.F., et al., 1996, Lien T.F., et al. (1996). The body's metabolic response to Cr depends on its chemical form, organic forms have higher bioavailability (10-25%) than inorganic sources (3%) (National Research Council (NRC), 1997, 1998). Accordingly, reducing CR particle size can increase the rate of digestion and absorption.
The use of chromium picolinate in the diet as an organic analogue may, depending on the dose, have different effects on the body, in particular high levels of crpic (more than 40 000 ppb, 0.32 mm) and biotic dose (50260 ppb) may stimulate the formation of hydroxyl radicals and damage the cells of Bagchi et al. (2002), Hepburn et al. (2002), Stearns et al. (1995), Speetjens et al. (1999), by contrast, no acute toxic effects were found in the administration of Crpic at a dose of 100 mg/kg of Anderson R.A., Bryden N.A., Polansky M.M. (1997).
Thus, the aim of the study was to study the effect of nanoparticles chromium and chromium picolinate on hematological parameters of blood in laboratory animals.

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