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Biochemical mechanisms of development of non-alcoholic fatty liver disease under the influence of fructose

DOI 10.18127/j20700997-201804-02


Z.Sh. Pavlova – Ph.D. (Med.), Endocrinologist, Medical Scientific-Educational Center of Lomonosov Moscow State University
I.I. Golodnikov – Faculty of Fundamental Medicine, Lomonosov Moscow State University
A.A. Kamalov - Academician of RAS, Dr.Sc. (Med.), Professor, Director of Medical Scientific-Educational Center of Lomonosov Moscow State University; Head of the Department of Urology and Andrology, Faculty of Fundamental Medicine, Lomonosov Moscow State University

With many changes in the life of a modern person, negatively affecting his health, for example, a sedentary lifestyle, a nonphysiological diet, the excessive use of fructose and its pathological effect on the metabolism of carbohydrates in the liver comes to the top. It's no secret that fructose has been considered a harmless alternative to glucose for patients with type 2 diabetes mellitus for quite some time, and confectionery products were prepared on its basis, which doctors recommended to patients. We need to sort out - fructose - a wolf in sheep's clothing or an affordable and safe sweetness.
The ability of fructose to be both a substrate and an inducer of the synthesis of lipids de novo [DNL] in the liver is the main cause of the development of NAFLD [Non-alcoholic fatty liver disease], and oxidative stress, mitochondrial dysfunction and inflammation is a physic consequence of events developing in excessively formed fat tissues, including the progression of simple steatosis of the liver in NAFLD. This article presents key participants and mechanisms responsible for the development of fructose-induced non-alcoholic fatty liver disease, as well as a number of stages of fructose metabolism, understanding of which is necessary to represent the process as a whole.

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