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A SQUID-based gradiometer for investigation of magnetic nanomarkers in bioobjects

Keywords:

Yu.V. Maslennikov - Dr.Sc. (Eng.), Pushkov Institute of Terrestrial Magnetism, Ionosphere and Radio Wave Propagation RAS (Moscow, Troitk); General Director, CRYOTON CO. LTD. (Moscow, Troitsk)
E-mail: cryoton@inbox.ru
V.Yu. Slobodchikov - Research Scientist, Kotel'nikov Institute of Radio Engineering and Electronics RAS (Moscow)
E-mail: slb@inbox.ru
V.A. Krymov - Ph.D. (Phys.-Math.), Senior Research Scientist, Kotel'nikov Institute of Radio Engineering and Elec-tronics RAS (Moscow)
E-mail: vkrymov@open.ru
V.V. Khanin - Leading Engineer, Kotel'nikov Institute of Radio Engineering and Electronics RAS (Moscow)
E-mail: volodja2@inbox.ru


A working laboratory sample of the SQUID-based gradiometer, which can be used to search and localize magnetic nanoparticles in bioobjects, was developed, created and tested. It demonstrated stable operation at laboratory conditions without additional magnetic shielding. Preliminary experiments on the registration of magnetic nanoparticles in test samples of small animals (rats) have been performed, high values of the «signal-to-noise» ratio were obtained for the samples studied. The principal possibility of using the SQUID-based gradiometers in the systems for controlling the transport of drugs on magnetic nanoparticles has been confirmed. Such SQUID-based systems can be specialized for use in medical complexes for diagnosis and treatment of oncological diseases.

References:
  1. Weissleder R., Elizondo G., Wittenberg J., Rabito C.A., Bengele H.H., Josephson L. Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging // Radiology. 1990. V. 175. Р. 489–493.
  2. Roger J., Pons J.N., Halbreich A., Bacri J.C., Roger J., Massart R. Some biomedical applications of ferrofluids // The European Physical Journal Applied Physics. 1999. V. 5. Р. 321325.
  3. Alexiou C., Arnold W., Klein R.J., Parak F.G., Hulin P., Bergemann C., Erhardt W., Wagenpfeil S., Lübbe A.S. Locoregional cancer treatment with magnetic drug targeting // Cancer Research. 2000. V. 60(23). P. 66416648.
  4. Babincova M., Altanerova V., Lampert M., Altaner C., Machova E., Sramka M., Babinec P. Site-specific in vivo targeting of magnetoliposomes using externally applied magnetic field // Z. Naturforsch. 2000. V. 55c. P. 278281.
  5. Kubo T., Sugita T., Shimose S., Nitta Y., Ikuta Y., Murakami T. Targeted delivery of anticancer drugs with intravenously administered magnetic liposomes in osteosarcoma-bearing hamsters // International journal of oncology. 2000. V. 17. P. 309315.
  6. Gallo J.M. and Häfeli U. Correspondence re: Lübbe A.S. et al. Preclinical and clinical experiences with magnetic drug targeting // Cancer Research. 1997. V. 57. P. 30633064.
  7. Lübbe A.S., Alexiou C., Bergemann C. Clinical Applications of Magnetic Drug Targeting // Journal of Surgical Research. 2001. V. 95. № 2. P. 200–206.
  8. Flynn E.R., Bryant H.C. A biomagnetic system for «in vivo» cancer imaging // Physics in Medicine and Biology. 2005. V. 50. P. 1273–1293.
  9. Johnson C., Adolphi N.L., Butler K.L., Lovato D.M., Larson R., Schwindt P.D.D., Flynn E.R. Magnetic relaxometry with anatomic magnetometer and SQUID sensors on targeted cancer cells // Journal of Magnetism and Magnetic Materials. 2012. V. 324. P. 2613-2619.
June 24, 2020
May 29, 2020

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