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Effect of thrombus formation on heat emission in Sputnik RBP

DOI 10.18127/j15604136-201805-13


Andrey Porfiryev - National Research University of Electronic Technology, Shokin Square 1, Zelenograd, Moscow, Russian Federation

Dmitry Telyshev - National Research University of Electronic Technology, Shokin Square 1, Zelenograd, Moscow, Russian Federation

Aleksandr Pugovkin - National Research University of Electronic Technology, Shokin Square 1, Zelenograd, Moscow, Russian Federation

Sergey Selishchev - National Research University of Electronic Technology, Shokin Square 1, Zelenograd, Moscow, Russian Federation


End-stage heart failure (HF) is a major cause of mortality, morbidity and disability worldwide. Nowadays, a surgical and medical treatment of HF has a positive trend. But heart transplantation remains an optimal treatment of endstage HF. A shortage of donor organs has made this therapy available only for limited number of patients (1). This problem required a development of ventricular assist devices (VADs) for critically ilium patients. The first devices had large dimension, but by the aid of engineering and technology developers have the opportunity to reduce the dimensions of VADs (2, 3). This feature allows the use of VADs for treatment of patients with small body surface area. However, the miniaturization of pump components may lead to a high hemolysis level (4, 5). Thrombus formation remains a serious problem of axial and centrifugal ventricular assist devices (6-8).

A typical construction of axial VAD consists of a flow straightener, an inlet bearing, an impeller, an outlet bearing and a diffuser in series, and a stator (9, 10). Mechanical friction between the pump components in such devices is accompanied by heat generation, which depends on the pump design (11).

Conversion of electrical energy to thermal energy is inherent for any motor under normal operation mode (12). Heat dissipation occurs due to thermal emissions from pump housing and heat transmission of blood moving through a device. Herewith excessive heat generation can adversely affect the blood hemolysis level and the protein denaturation increasing the probability of thrombus formation (13). As a result the pump failure probability increases. This problem can be solved only by emergency surgery with full replacement of implanted VAD (14, 15). Currently, the influence of thrombosis on a rotary blood pump heat generation is not fully investigated. Therefore, in vitro tests were conducted in hydraulic closed loop using the rotary blood pump of the Sputnik VAD to determine the nature of heat generation for different conditions which are typical for implantable systems. Since 2012 the Sputnik VAD successfully used to replace of left ventricular function for patients with HF. This VAD is the axial and continuous flow pump.

  1.   Y. Ohashi, A. Andrade and Y. Nose. Hemolysis in an elec- tromechanical driven pulsatile total artificial heart. Artif Or- gans,27(12):1089-1093, 2003.
  2.  A. Cheung, K. Chorpenning and et al. Design concepts and preclinical results of a miniaturized HeartWare platform: The MVAD System. Innovations (Phila), 10(3):151-6, 2015.
  3.  I. Adachi, S. Burki, F. Zafar and D.L. Morales. Pediatric ventricular assist devices. J Thorac Dis, 7(12): 2194–2202, 2015.
  4.  J. Garbade, H.B. Bittner, S. Lehmann, F.W. Mohr and M.J. Barten. Miniaturization of left ventricular assist devices: the ongoing trend. Expert Rev Med Devices, 9(1):49-58, 2012.
  5.  T. Takano, S. Schulte-Eistrup and et al. Impeller inner di- ameter in a miniaturized centrifugal blood pump. Artif Or- gans, 26(1):67-71, 2002.
  6.  V. Tchantchaleishvili, F. Sagebin, R.E. Ross, W. Hallinan, K.Q. Schwarz and H.T. Massey. Evaluation and treatment of pump thrombosis and hemolysis. Ann Cardiothorac Surg, 3(5):490-495, 2014.
  7.  D.J. Goldstein, R. John and et al. Algorithm for the diagno- sis and management of suspected pump thrombus. J Heart Lung Transplant, 32(7):667-70, 2013.
  8.  J.K. Kirklin, D.C. Naftel and et al. Pump thrombosis in the Thoratec HeartMate II device: an update analysis of the IN- TERMACS Registry. J Heart Lung Transplant, 34:1515-26, 2015.
  9.  F.H. Sheikh and S.D. Russell. HeartMate II continuous-flow left ventricular assist system. Expert Rev Med Devices, 8(1):11-21, 2011.
  10.  M.P. Macris, S.M. Parnis, O.H. Frazier, J.M. Fuqua Jr and R.K. Jarvik. Development of an implantable ventricular as- sist system. Ann Thorac Surg, 63(2):367-70, 1997.
  11.  T. Kink and H. Reul. Concept for a new hydrodynamic blood bearing for miniature blood pumps. Artif Organs, 28(10):916-20, 2004.
  12.  L. Chen, Y. Pei, F. Chai and S. Cheng. Investigation of a novel mechanical to thermal energy converter based on the inverse problem of electric machines. Energies, 9(7):1-19, 2016.
  13.  K. Araki, Y. Taenaka and et al. Hemolysis and heat genera- tion in six different types of centrifugal blood pumps. Artif Organs, 19(9):928-32, 1995.
  14.  J.K. Kirklin, D.C. Naftel and R.L. Kormos. The fourth IN- TERMACS annual report: 4,000 implants and counting. J Heart Lung Transplant, 31:117–126, 2012.
  15.  M.S. Slaughter, J.G. Rogers and et al. HeartMate II Investi- gators: Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med, 361:2241-2251, 2009.
  16.  S.V. Selishchev and D.V. Telyshev. Ventricular Assist De- vice Sputnik: Description, technical features and characteris- tics. Trends Biomater Artif Organs, 29(3):207-210, 2015.
  17.  S.V. Selishchev and D.V. Telyshev. Optimisation of the Sputnik-VAD design. Int J Artif Organs, 39(8):407-414, 2016.
  18.  T.K. Yasar, T.J. Royston and R.L. Magin. Wideband MR elastography for viscoelasticity model identification. Magn Reson Med, 70(2): 479-489, 2013.
  19.  J.B. Segur and H.E. Oberstar. Viscosity of glycerol and its aqueous solutions. Ind Eng Chem, 43(9):2117-2120, 1951.
  20.  N.L. Gershfeld and M. Murayama. Thermal instability of red blood cell membrane bilayers: temperature dependence of hemolysis. J Membr Biol, 101:67–72, 1988.
  21.  F. Kaufmann and T. Krabatsch. Using medical imaging for the detection of adverse events ("incidents") during the utili- zation of left ventricular assist devices in adult patients with advanced heart failure. Expert Rev Med Devices, 13(5):463- 74, 2016.
  22.  A. Blitz. Pump thrombosis - a riddle wrapped in a mystery inside an enigma. Ann Cardiothorac Surg, 3(5):450-471, 2014.  
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