Radiotekhnika
Publishing house Radiotekhnika

"Publishing house Radiotekhnika":
scientific and technical literature.
Books and journals of publishing houses: IPRZHR, RS-PRESS, SCIENCE-PRESS


Тел.: +7 (495) 625-9241

 

Involvement of melatonin in mechanisms of antinocicep-tive effect of EHF therapy

Keywords:

N.A. Temuryants Dr.Sc. (Biol.) (1945–2018)
K.N. Tumanyants Ph.D. (Biol.), Director, V.I. Vernadsky Crimean Federal University (Simpheropol)
E-mail: tumanyantsk@gmail.com
E.N. Chuyan Dr.Sc. (Biol.), Professor, V.I. Vernadsky Crimean Federal University (Simpheropol)
E-mail: timur328@gmail.com
E.N. Tumanyants Ph.D. (Med.), Senior Research Scientist, V.I. Vernadsky Crimean Federal University (Simpheropol)
E-mail: timur328@gmail.com
A.S. Kostyuk Ph.D. (Biol.), Assistant, Kiev National University n.a. after Taras Shevchenko
E-mail: timur328@gmail.com
N.S. Yarmolyuk Ph.D. (Biol.), Associate Professor, V.I. Vernadsky Crimean Federal University (Simpheropol)
E-mail: timur328@gmail.com


To broaden our understanding of the role of melatonin (MT) in the mechanisms underlying the action of electromagnetic factors, we studied MT effects and electromagnetic radiation (EMR) of extremely high frequency (EHF) on nociception of molluscs and its infradian rhythm dynamics. There was found that both factors cause the comparable changes in noceception and decrease screened and desynchronosis. We hypothesize that EMR EHF, after absorbtion in the skin, modulate the synthesis of MT in the components of the serotonin / melatoninergic system.

References:
  1. Devjatkov N.D., Golant M.B., Beckij O.V. Millimetrovye volny i ih rol' v processah zhiznedejatel'nosti. M.: Radio i svjaz'. 1991. 168 s.
  2. Hardeland R., Poeggeler B. Non-vertebrate melatonin // J. Pineal Res. 2003. V. 34. Is. 4. P. 233–241.
  3. Tan D.X., Manchester L.C., Reiter R.J., Qi W.B., Karbownik M., Calvo J.R. Significance of melatonin in antioxidative defense system: reactions and products // Biol Signals Recept. 2000. V. 9. Is. 3–4. P. 137–159.
  4. Reiter R.J., Mayo J.C., Tan D.X., Sainz R.M., Alatorre-Jimenez M., Qin L. Melatonin as an antioxidant: under promises but over delivers // J. Pineal Res. 2016. V. 61. Is. 3. Р. 253–78.
  5. Semm P., Schneider Т., Vollratch L. Effects of Earth-strength magnetic field on electrical activity of pineal cells // Nature. 1980. V. 288. P. 607–608.
  6. Wilson B.W., Anderson L.E., Hilton D.I., Phillips R.D. Chronic exposure to 60 Hz electric fields: effects on pineal function in the rat // Bioelectromagnetics. 1981. V. 2. Is. 4. P. 371–380.
  7. Touitou Y., Selmaoui B. The effects of extremely low-frequency magnetic fields on melatonin and cortisol, two marker rhythms of the circadian system // Dialogues in Clinical Neuroscience. 2012. V. 14. Is. 4. P. 381–399.
  8. Lewczuk B., Redlarski G., Żak A., Ziółkowska N., Przybylska-Gornowicz B., Krawczuk M. Influence of Electric, Magnetic, and Electromagnetic Fields on the Circadian System: Current Stage of Knowledge // BioMed. Research. International. 2014. V. 2014. P. 13.
  9. Pfluger D.H., Minder C.E. Effects of exposure to 16.7 Hz magnetic fields on urinary 6-hydroxymelatonin sulfate excretion of Swiss railway workers // J. Pineal Research. 1996. V. 21. Is. 2. P. 91–100.
  10. Kato M., Honma K., Shigemitsu T., Shiga Y. Effects of exposure to a circularly polarized 50-Hz magnetic field on plasma and pineal melatonin levels in rats // Bioelectromagnetics. 1993. V. 14. Is. 2. P. 97–106.
  11. Selmaoui B., Touitou Y. Sinusoidal 50-Hz magnetic fields depress rat pineal nat activity and serum melatonin: role of duration and intensity of exposure // Life Sciences. 1995. V. 57. Is. 14. P. 1351–1358.
  12. Rapoport S.I., Bol'shakova H.D., Malinovskaja N.K., Meshherjakova S.A., Oraevskij V.N., Breus T.K., Sosnovskij A.M. Magnitnye buri kak stress // Biofizika. 1998. T. 43. № 4. S. 632–639.
  13. Burch J.B., Reif J.S., Yost M.G. Geomagnetic disturbances are associated with reduced nocturnal excretion of a melatonin metabolite in humans // Neurosci. Lett. 1999. V. 266. P. 209–212.
  14. Ismailov V.A., Koshelevskij V.K. Vlijanie variacij geomagnitnogo polja na cirkadiannuju aktivnost' jepifiza // Problemy gerontologii. 2008. T. 21. № 3. S. 382–385.
  15. Reiter R.J., Anderson L.E., Buschbom R.L., Wilson B.W. Reduction of the nocturnal rise in pineal melatonin levels in rats exposed to 60-Hz electric fields in utero and for 23 days after birth // Life Sci. 1988. V. 42. Is. 22. P. 2203–2206.
  16. Cremer–Bartels G., Krause К., Kuchle H.J. Influence of low magnetic–field–strength variations on the retina and pineal gland of quail and humans // Graefes Arch. Clin. Exp. Ophthaimoi. 1983. V. 220. Is. 5. P. 248–252.
  17. Bakos J., Nagy N., Thuróczy G., Szabó L.D. Urinary 6-sulphatoxymelatonin excretion is increased in rats after 24 hours of exposure to vertical 50 Hz, 100 microT magnetic field // Bioelectromagnetics. 1997. V. 18. Is. 2. P. 190–192.
  18. Kumlin T., Heikkinen P., Laitinen J.T., Juutilainen J. Exposure to a 50-hz magnetic field induces a circadian rhythm in 6-hydroxymelatonin sulfate excretion in mice // J. Radiat. Res. 2005. V. 46. P. 313–318.
  19. Anisimov V.N. Jepifiz, melatonin, starenie // Hronobiologija i hronomedicina. Rukovodstvo. M.: OOO Medicinskoe informacionnoe agentstvo. 2012. S. 284–333.
  20. Zaslavskaja R.M. Optimizacija lechenija meteo- i magnitochuvstvitel'nyh bol'nyh arterial'noj gipertenziej i ishemicheskoj bolezn'ju serdca s ispol'zovaniem adaptogenov. M.: Medpraktika. 2012. 256 s.
  21. Srinivasan V., Lauterbach E.C., Ho K.Y., Acuna-Castroviego D., Zakaria R., Brzezinsky A. Melatonin in antinociception: its therapeutic applications // Curr. Neuropharmacol. 2012. V. 10. Is. 2. P. 167–178.
  22. Samuels C.H. Jet lag and travel fatigue: a comprehensive management plan for sport medicine physicians and high-performance support teams // Clin. J. Sport Med. 2012. V. 22. Is. 3. P. 268.
  23. Temur'janc N.A., Tumanjanc K.N., Husainov D.R., Cheretaev I.V., Tumanjanc E.N. Uchastie melatonina v izmenenii depressivnopodobnogo i agressivnogo povedenija krys pri umerennom jelektromagnitnom jekranirovanii // Geofizicheskie processy i biosfera. 2016. T. 15. № 3. S. 67–85.
  24. Chujan E.N., Dzheldubaeva Je.R. Mehanizmy antinociceptivnogo dejstvija nizkointensivnogo millimetrovogo izluchenija. Simferopol': «DIAJPI». 2006. 508 s.
  25. Radzievsky A.A., Gordiienko O.V., Alekseev S., Szabo I., Cowan A., Ziskin M.C. Electromagnetic millimeter wave induced hypoalgesia: frequency dependence and involve¬ment of endogenous opioids // Bioelectromagnetics. 2008. V. 29. Is.8. P. 284–295.
  26. Temur'janc N.A., Kostjuk A.S., Tumanjanc K.N. Uchastie melatonina v izmenenii nocicepcii molljuskov i myshej pri dlitel'nom jelektromagnitnom jekranirovanii // Rossijskij fiziologicheskij zhurnal im. I.M. Sechenova. 2013. T. 99. № 11. S. 1333–1341.
  27. Temur'janc N.A., Kostjuk A.S., Tumanjanc K.N. Vlijanie nizkointensivnogo jelektromagnitnogo izluchenija kraj¬ne vysokoj chastoty na bolevuju chuvstvitel'nost' molljuskov Helix albescens // Millimetrovye volny v biologii i medicine. 2010. T. 23(62). № 1. C. 39–45.
  28. Devicin D.V., Pal'chikova N.A., Trofimov A.V., Seljatickaja V.G., Kaznacheev V.P. Dinamika fiziolo-gicheskih harakteristik i jemocional'no-povedenches-koj reaktivnosti zhivotnyh v preformirovannoj geomagnitnoj srede // Bjulleten' SO RAMN. 2005. T. 25. № 3. S. 71–77.
  29. Temur'janc N.A., Tumanjanc K.N. Vlijanie nizkointensivnyh jelektromagnitnyh izluchenij krajne vysokoj i krajne nizkoj chastot na razvitie jekranobuslovlennogo desinhronoza // Biomedicinskaja radiojelektronika. 2015. № 8. S. 47–55.
  30. Prato F.S. Light–dependent and – independent behavioral effects of extremely low frequency magnetic fields in a land snail are consistent with a parametric resonance mechanism // Bioelectromagnetics. 1997. V. 18. Is. 3. P. 284–291.
  31. Lakin M.L. Involvement of the pineal gland and melatonin in murine analgesia // Life Sci, 1981. V. 29(24). Р. 2543–2551.
  32. Rojavin M.A., Ziskin M.C. Medical application of millimetre waves // Q. J. Med. 1998. V. 91. P. 57–66.
  33. Chujan E.N., Temur'janc N.A., Moskovchuk O.B. i dr. Fiziologicheskie mehanizmy biologicheskih jeffektov nizkointensivnogo JeMI KVCh. Simferopol': ChP «Jel'in'o». 2003. 448 s.
  34. Arushanjan Je.B. Universal'nye terapevticheskie vozmozhnosti melatonina // Klinicheskaja medicina. 2013. T. 91(2). S. 4–8.
  35. Opie L.H., Lecour S. Melatonin has multiorgan effects // Eur Heart J. Cardiovasc. Pharmacother. 2016. V. 2. P. 258–265.
  36. Malhotra S., Sawhney G., Pandhi P. The therapeutic potential of melatonin: a review of the science // Med. Gen. Med. 2004. V. 6. Is. 2. P. 46.
  37. Esposito E., Cuzzocrea S. Antiinflammatory activity of melatonin in central nervous system // Curr. Neuro¬pharmacol. 2010. V. 8. Is 3. Р. 228–242.
  38. Slominski A., Wortsman J. Neuroendocrinology of the skin // Endocr. Rev. 2000. Is. 21(5). P. 457–487.
  39. Zmijewski M.A., Slominski A.T. Neuroendocrinology of the skin // Dermato-Endocrinology. 2011. Is. 3. № 1. P. 3–10.
  40. Arck P.C., Slominski A., Theoharides T.C., Peters E.M., Paus R. Neuroimmunology of stress: skin takes center stage // J. Invest Dermatol. 2006. V. 126. Is. 8. Р. 1697–704.
  41. Slominski A., Wortsman J., Tobin D.J. The cutaneous serotoninergic/melatoninergic system: securing a place under the sun // FASEB J. 2005a. Is. 19. № 2. P. 176–194.
  42. Slominski A., Fischer T.W., Zmijewski M.A., Wortsman J., Semak I., Zbytek B., Slominski R.M., Tobin D.J. On the role of melatonin in skin physiology and pathology // Endocrine. 2005b. Is. 27(2). Р.137–48.
  43. Slominski A., Tobin D.J., Zmijewski M.A., Wortsman J., Paus R. Melatonin in the skin: synthesis, metabolism and functions // Trends Endocrinol Metab. 2008. Is. 19(1). Р. 17–24.
  44. Fischer T.W., Sweatman T.W., Semak I., et al. Constitutive and UV-induced Metabolism of Melatonin in Keratinocytes and Cell-Free Systems // FASEB J. 2006. Is. 20. Р. 1564–1566.
  45. Johansson O., Virtanen M., Hilliges M. Histaminergic nerves demonstrated in the skin. A new direct mode of neuro¬genic inflammation // Exp. Dermatol. 1995. V. 4. Is. 2. P. 93–96.
  46. Lebedeva N.N. Neurophysiological mechanisms of low intensity electromagnetic fields biological effects // Radiotekhnika. 1997. V. 4. P. 62–66.
  47. Akoev G.N., Avelev V.D., Semen'kov P.G. Vosprijatie jelektromagnitnogo izluchenija millimetrovogo diapazona jelektroreceptorov skatov // Tezisy dokl. Vsesojuznogo soveshhanija po jevoljucionnoj fiziologii. L.: Nauka. 1990. S. 45.
  48. Slominski R.M., Reiter R.J., Loutsevitch N.S., Ostrom R.S., Slominski A.1. Melatonin membrane receptors in peripheral tissues: Distribution and functions // Molecular and Cellular Endocrinology. 2012. Is. 351. P. 152–166.
  49. Popov V.I., Rogachevskij V.V., Gapeev A.B., Hramov R.N., Chemeris N.K., Fesenko E.E. Degranuljacija tuchnyh kletok kozhi pod dejstviem nizkointensivnogo jelektromagnitnogo izluchenija krajne vysokoj chastoty // Biofizika. 2001. T. 46. № 6. S. 1096–1102.
  50. Alekseev S.I., Gordiienko O.V., Radzievsky A.A. et al. Millimeter wave effects on electrical responses of the sural nerve in vivo // Bioelectromagnetics. 2010. V. 31. Is. 3. P. 180–190.
  51. Gangi S., Johansson O. A theoretical model based upon mast cells and histamine to explain the recently proclaimed sensitivity to electric and/or magnetic fields in humans // Medical Hypothesis. 2000. V. 54. P. 663–671.
  52. Dubocovich M.L., Markowska M. Functional MT1 and MT2 melatonin receptors in mammals // Endocrine J. 2005. V. 27. P. 101–110.
  53. Dubocovich M.L., Yun K., Al-Ghoul W.M., Benloucif S., Masana M.I. Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms // FASEB J. 1998. V. 12. P. 1211–1220.
  54. Baler R., Coon S., Klein D.S. Orphan nuclear receptor Rzr-beta-cyclic-AMP regulates expression in the pineal gland // Biochem. biophys. Res. Commun. 1996. V. 220. P. 975–978.
  55. Wu Y.H., Zhou J.N., Balesar R. et al. Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland: colocalization of MT1 with vasopressin, oxytocin, and corticotropin – releasing hormone // J. Comp. Neurol. 2006. V. 499. Is. 6. P. 897–910.
  56. Novikova N.S., Perekrest S. V., Rogers V. J. [et al.] Morphometric analysis of hypothalamic cells showing c–Fos proteins after movement restriction and EHF – irradiation // Pathophysiology. 2008. V. 15. Is.1. P. 19–24.
  57. Novikova N.S., Kazakova T.B., Rogers V. et al. Expression of the c-For gene in the rat hypothalamus in electrical pain stimulation and UHF stimulation of the skin // Neuroscience and behavioral physiology. 2008. V. 38. Is. 4. P. 415–420.
  58. Herman J.P., Cullman W.E. Neurocircuitry of stress; central control of the hypothala-вю-pituitary-adrenocortical axis // Trends Neurosci. 1997. V. 20. P. 78–84.
  59. Imaki T., Shibasaki T., Demura H. Regulation of gene expression in the central nervous system by stress: molecular pathways of stress responses // Endocrine J. 1995. V. 42. Is. 2. P. 121–130.
  60. Kazakova T.B., Barabanova S.V., Novikova N.S. et al. Induction of c–fos and interleukin–2 genes expression in the central nervous system following stressor stimuli // Int. J. Pathol. 2000. V. 7. P. 53–61.
  61. Bragin E.O. Nejrohimicheskie mehanizmy reguljacii bolevoj chuvstvitel'nosti. M.: Izd-vo RUDN. 1991. 247 s.
  62. Martynjuk V.S., Temur'janc N.A., Moskovchuk O.B. Korreljacija biofizicheskih parametrov biologicheski aktivnyh tochek i variacij geliogeofizicheskih faktorov // Biofizika. 2001. T. 46. № 5. S. 905–909.
  63. Teppermen D., Teppermen H. Fiziologija obmena veshhestv i jendokrinnoj sistemy, M.: Mir, 1989. 656 s.
  64. Bittman E.L. Vasopressin: more than just an output of the circadian pacemaker? Focus on «Vasopressin receptor V1a regulates circadian rhythms of locomotor activity and expression of clock-controlled genes in the suprachiasmatic nuclei». AJP // Regul. Integr. Comp. Physiol. 2009. 296. R821–R823.
  65. Kalsbeek A., Verhagen L.A., Schalij I. et al. Opposite actions of hypothalamic vasopressin on circadian corticosterone rhythm in nocturnal versus diurnal species // Eur. J. Neurosci. 2008. V. 27. P. 818–827.
  66. Temur`janc N.A., Shehotkin O.V. Rol' epіfіza v organіzacії іnfradіannoї ritmіki fіzіologіchnih sistem // Nejrofiziologija. 1999. T. 31. № 2. S. 157–161.
  67. Vorob'ev V.V., Gapeev A.B., Nejman A. i dr. Chastotnyj sostav JeJeG simmetrichnyh oblastej kory i gippokampa krolikov pri vozdejstvii JeMI KVCh na zonu akupunktury // Vestnik novyh medicinskih tehnologij. 1999. T. VI. № 1. S. 23–27.
  68. Chujan E.N., Temur'janc N.A., Ponomareva V.P. i dr. Funkcional'naja asimmetrija u cheloveka i zhivotnyh: vlijanie nizkointensivnogo jelektromagnitnogo izluchenija millimetrovogo diapazona. Simferopol'. 2004. 440 s.
  69. Hramov R.N., Vorob'ev V.V., Bratkova L.R. «Triggernye» JeJeG jeffekty ul'trafioletovogo sveta v uslovijah ego hronicheskogo primenenija // Doklady AN. 1997. T. 356. № 3. S. 418–421.
  70. Makarova I. Usilenie naprjazhenija magnitnogo polja Zemli izmenjaet aktivnost' pravogo polusharija mozga // Tezisy dokl. II Mezhdunar. kongressa «Slabye i sverhslabye polja i izluchenija v biologii i medicine». SPb: Tuskarora. 2000. S. 42–43.
June 24, 2020
May 29, 2020

© Издательство «РАДИОТЕХНИКА», 2004-2017            Тел.: (495) 625-9241                   Designed by [SWAP]Studio