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Metabolism of homocystein and cystein role in breast cancer


N.E. Kushlinskii – Dr.Sc. (Med.), Professor, Member-Correspondent of Russian Academy of Sciences, N.N. Blokhin National Medical Cancer Research Center (Moscow)
E.I. Alekseeva – Post-Graduate Student, N.N. Blokhin National Medical Cancer Research Center (Moscow)
A.V. Ivanov – Ph.D. (Biol.), Institute of General Pathology and Pathophysiology (Moscow)
E.A. Avilova – Ph.D. (Med.), N.N. Blokhin National Medical Cancer Research Center (Moscow)
E.S. Gershtein – Dr.Sc. (Biol.), Professor, N.N. Blokhin National Medical Cancer Research Center (Moscow)
A.A. Kubatiev – Dr.Sc. (Med.), Professor, Academician of Russian Academy of Sciences, Institute of General Pathology and Pathophysiology (Moscow)

Interest in studying metabolic characteristics of thiol-containing amino acids (cysteine and homocysteine) in breast cancer is imposed by the ongoing search for new biomarkers and therapeutic approaches, such as metabolic starvation. This re-view describes the role of metabolic pathways (methionine cycle and transsulfuration) in mammary gland carcinogenesis, as well as the prospects of cysteine and homocysteine application in clinical and laboratory diagnostics of breast cancer. Despite the fact that the metabolism of these amino acids in this pathology has been actively studied for more than a dec-ade and numerous studies have shown their important role in breast cancer development, the results of clinical trials are contradictory.

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