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The behavior of rats with intranasal exposure to a small dose of single-walled carbon nanotubes

Keywords:

E.V. Loseva – Dr.Sc. (Biol.), Chief Research Scientist of Labofrtory of Functional Neurocytology, Institute of Higher Nervous Activity and Neurophysiology RAS (Moscow)
E-mail: losvnd@mail.ru
N.A. Loginova – Ph.D. (Biol.), Senior Research Scientist of Laboratory of Functional Neurocytology, Institute of Higher Nervous Activity and Neurophysiology RAS (Moscow)
E-mail: nadezhda.loginova1982@gmail.com
L.I. Russu – Research Scientist, Laboratory of Tissue Cultures, D.I. Ivanovskii Institute of Virusology, Gama-leya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation (Moscow)
E-mail: plano77@bk.ru
M.V. Mezentseva – Dr. Sc., Head of the Laboratory of Tissue Cultures, D.I. Ivanovskii Institute of Virusology, Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation (Moscow)
E-mail: marmez@mail.ru


It was studied the effect of intranasal administration of single-walled carbon nanotubes (SWCNT) in a small dose (5.2 μg / kg) on the behavior of rats in common anxiety tests. It was shown, that at rats, who only once received a small dose of SWCNT, the anxiety behavior in the «open field» test was increased. In the «light-darkness» and «elevated plus maze» tests, the rats, after 3 or 4-fold administration of a small dose of SWCNT, demonstrated behavioral overactivity, which was expressed by the frequent and prolonged exits to a light box or to open arms and by the increase of vertical and horizontal activity. That is, even a short intranasal administration of a small dose of SWCNT can change the behavior of animals, increasing their anxiety or leading to overactivation.

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