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Genetic predictors of long-term prognosis in patients with myocardial infarction

Keywords:

M.V. Solodun – Post-graduate Student, Ryazan State Medical University Е-mail: mariyasolodun@mail.ru S.S. Yakushin – Dr.Sc. (Med.), Professor, Ryazan State Medical University Е-mail: ssyakushin@yandex.ru


To analyze the prognostic value of gene polymorphisms ACE (D/I), SLCO1B1 (Val174Ala), LIPC (C514T), CYP2C19*2, CYP2C19*3, ADRB1 (Ser49Gly), ADRB1 (Arg389Gly) of patients with ST-segment elevation myocardial infarction (STEMI). 155 patients with STEMI were involved into the study. All patients were prescribed all recommended preparations improving prognosis from the first day of hospitalization. Prognosis was assessed by a combined endpoint, including cardiovascular mortality, nonfatal myocardial infarction, unplanned revascularization of coronary arteries and hospitalization for unstable angina, throughout 12 months. The II genotype of the polymorphic gene ACE (I/D) is an independent predictor of the 12-month STEMI favorable outcome. Allele Ser of the polymorphic gene ADRB1 Ser49Gly is associated with an increased incidence of adverse cardiovascular events within 12 months after STEMI.
References:

 

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