Radiotekhnika
Publishing house Radiotekhnika

"Publishing house Radiotekhnika":
scientific and technical literature.
Books and journals of publishing houses: IPRZHR, RS-PRESS, SCIENCE-PRESS


Тел.: +7 (495) 625-9241

 

Development of therapeutic cholinic diet with the use of a method of mathematical simulation with the experimental injury of the brain

Keywords:

M.V. Guseva – Leading Engineer, Chair of Embryology of Biological Department, Lomonosov Moscow State University. E-mail: Maria.Guseva@fresenius-kabi.com V.B. Gusev – Ph.D. (Phys.-Math.), Head of Laboratory of Self-Developing Systems Control, V.A. Trapeznikov Institute of Control Sciences Problem RAS (Moscow). E-mail: gusvbr@mail.ru A.M. Anokhin – Ph.D. (Eng.), Senior Research Scientist, Laboratory of Self-Developing Systems Control, V.A. Trapeznikov Institute of Control Sciences Problem RAS (Moscow). E-mail: amanohin@mail.ru A.A. Kamensky – Dr.Sc. (Biol.), Professor, Human and Animal Physiology of Biological Department, Lomonosov Moscow State University T.K. Dubovaya – Dr.Sc. (Med.), Professor, Department of Histology, Embryology and Cytology, N.I. Pirogov Russian National Research Medical University (Moscow). E-mail: dubovaya@mail.ru


The mathematical model of the influence of the content of choline in the food ration of rats on the dynamics of the expression of the nicotine receptors of acetylcholine (α7 nAChR) in the brain, the dynamics of the mass of the body of animals, quantity of food consumed by them and water is built. Model was identified on the obtained earlier experimental data about the reaction of the organism of rats on a variation in the cholinic diet. The method of calculation of rational cholinic diet under the conditions of the contusion of the brain of the rats of medium-weight degree is developed on the basis of mathematical model. Within the framework of the developed and identified model it was shown that the diet proposed can ensure the required level of the expression of α7 nAChR, aimed at an improvement in the morphofunctional state of the traumatized brain. This index is connected with the state of the cognitive processes of the traumatized brain. The selection of diets made it possible to obtain two regimes that correspond to the requirements indicated, but characterizing by the accompanying consequences. For the 1st regime the first week adapts the diet with a constant increased content choline, and then each day the content of choline in the diet increases by 0.2%, which led to the defect of increase in the mass of the body of animals. For decreasing this effect the calculation of 2nd type diet, which includes the stages of remission due to the periodic decreases of the dose of food choline, is carried out. The results of work can be useful for the optimization of the effect of choline with the injury of brain.
References:

 

  1. Daminov V.D., Germanovich V.V. Primenenie Gliatilina v kompleksnom lechenii bolnykh, perenesshikh cherepno-mozgo­vuju travmu // ZHurnal Farmateka. 2007. № 15(149). S. 70–73.
  2. Guseva M.V., Hopkins D.M., PaulyJ.R. An autoradiographic analysis of rat brain nicotinic receptor plasticity following dietary choline modification // Pharmacology, Biochemistry and Behavior. 2006. V. 84(1). P. 26–34.
  3. Klein J, Koppen A, Loffelholz K.Regulation of free choline in rat brain: dietary and pharmacological manipulations // Neuro­chem. Int. 1998. V.32. P. 479–485.
  4. Morley B.J., Fleck D.L. A time course and dose-response study of the regulation of brain nicotinic receptors by dietary choline // Brain Res. 1987. V.421. P. 21–29.
  5. Allen D.D., Smith Q.R. Blood-brain barrier choline transport in the senescent rat // Neurosci. Lett. 1999. V. 277. P. 198–202.
  6. Guseva M.V., Hopkins D.M., Scheff S.W., Pauly J.R. Dietary choline supplementation improves behavioral, histological, and neurochemical outcomes in a rat model of traumatic brain injury // J. Neurotrauma. 2008. №25(8). P. 975–983.
  7. Guseva M.V., Kamenskijj A.A., Gusev V.B. Issledovanie dinamiki otvetnojj reakcii organizma na izmenenie soderzha­nija kholina v pishhevom racione krys // Bjulleten ehksperimentalnojj biologii i mediciny. 2012. № 7. S. 11–13.
  8. Mogilevskaya E., Bagrova N., Plyusnina T., Gizzatkulov N., Metelkin E., Goryacheva E., Smirnov S., Kosinsky Y., Dorodnov A.,Peskov K., Karelina T., Lebedeva G., Goryanin I. and Demin O. Kinetic modeling as a tool to integrate multilevel dynamic experimental data // Methods Mol. Biol. 2009. V.563. P.197–218. 

 

May 29, 2020

© Издательство «РАДИОТЕХНИКА», 2004-2017            Тел.: (495) 625-9241                   Designed by [SWAP]Studio