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Nano-effects in molecular hinges of ionic channels of neuronic cellular membrane and neurocomputing simulation of threshold waves nature

Keywords:

A. V. Savelyev – Senior Research Scientist, Deputy Editor in Chief of the Journal «Neurocomputers: development, application», «Radio Engineering» Publisher (Moscow). E-mail: gmkristo@yandex.ru


In this paper of the author\'s results of several years research on the detailed modeling of nano-processes of the nervous system at the cellular and molecular level is contained. It concerns of wave propagation of changes the excitability threshold of neuronal membranes in neural networks, and determine the nature of this phenomenon in nano-size level. An attempt is made to clarify some misunderstanding of relationships of space-time dynamics in spike propagation and the associated change in the threshold of the nerve fibers, as well as cause-effect relationships that. Characteristics connection of such a nature waves with ahead of the changes in the threshold of the next fiber, relative to the propagating spike is proven. The propagation of the threshold wave itself is a very remarkable phenomenon in neurons and may determine specific additional communication mechanism, no less important than the spike propagation of excitation, at the same time, directly associated with it. Difference between the open (MvAP) and closed KirBac1.1 (KcsA) potassium chan¬nel, which is the internal geometry of protein helices that form the lining of the pore are shown and simulated. M and S-helix in the case of lateral opening channel have a break, due to the fact that the nanostructural contain weakened middle section between two heavy duty C and N-terminal. Spiral fracture is localized in areas with glycine residues, as we know, highly conserved in potassium channels. They, just, and act as a flexible hinge due to increased conformational flexibility, providing a spiral fracture in these places. Activating force causes the slope of the outer spirals, and their interaction with internal coils, causing them to break. In potentsial-sensitive channel voltage-sensing S4 segment is adjacent to the outer helix S5, exercising its slope and, therefore, the subsequent break in the inner helix. In addition, the overall mobility of the hinge system of channels affected by changes in hydrophobicity protein, which has the character of a noise signal. In this case, the impact of passing electrical spike are determinative of the flexible hinge nanosystems behavior, blocking its stochastic fluctuations. Electrogenic and electro-efficiency threshold waves and their possible non-electromagnetic nature, namely, mechanical or mechanical and chemical is shown. Characteristics connection just such a nature waves ahead of the changes in the threshold of the next fiber, relative to the propagating spike is proved. Simulations showed the possibility of influences, and, cross-cutting nature, through the electromagnetic field of the propagating spike, which is powerful enough electrical artifact. In addition, these models can reproduce makro-effects of collective order are caused a collective nano-effects of change in the mobility of molecular nano-hinges of membrane channel proteins. Simulation results of neuronal membrane nano¬processes in the level of information macromodels are presented, the possibility of playing their mechanisms at the macro level and compatibility of nano- and neural information technology is shown.
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