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The impact of single-walled carbon nanotubes on the synthesis of cytokines and the c-fos expression in the rat brain

Keywords:

M. V. Mezentseva – Dr.Sc. (Biol.), Head of the Laboratory of Tissue Cultures, D.I. Ivanovsky Institute of Virology (Moscow). E-mail: marmez@mail.ru
L. I. Russu – Research Scientist, Laboratory of Tissue Cultures, D.I. Ivanovsky Institute of Virology, Moscow. E-mail: plano77@bk.ru
E. V. Loseva – Dr.Sc. (Biol.), Principal Research Scientist, Laboratory of Functional Neurocytology, Institute of Higher Nervous Activity and Neurophysiology of RAS (Moscow). E-mail: losvnd@mail.ru
N. A. Loginova – Ph.D. (Biol.), Research Scientist, Laboratory of Functional Neurocytology, Institute of Higher Nervous Activity and Neurophysiology of RAS (Moscow). E-mail: nadinvnd@yandex.ru
N. V. Panov – Assistant, Laboratory of Functional Neurocytology, Institute of Higher Nervous Activity and Neurophysiology of RAS (Moscow). E-mail: nikolay.panov1966@yandex.ru
M. N. Schcetvin – Research Scientist, Laboratory of Tissue Cultures, D.I. Ivanovsky Institute of Virology (Moscow)
I. A. Suetina – Ph.D. (Biol.), Leading Research Scientist, Laboratory of Tissue Cultures, D.I. Ivanovsky Institute of Virology (Moscow)


It is shown that in 24 hours after intranasal introduction of single-walled carbon nanotubes (SWCN) to rats, according to immunological analysis of some cytokines expression, Th1-type of immune response activated in posterior part and Th2-type activated in anterior part of the brain. In the same time, according to immunohistochemical study, introduction of SWCN didn't influence on c-fos expression in all studied brain structures. That is, the activity of a brain didn't change.
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