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Medicative and preventive action of bienzyme superoxide dismutase  chondroitin sulphate – catalase conjugate at endotoxic shock

Keywords:

A.V. Maksimenko – Dr. Sc. (Biol.), Professor, Head of Biochemical Engineering Laboratory, Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Moscow, Russia. E-mail: alexmak@cardio.ru
A.V. Vavaeva – Junior Research Scientist of Biochemical Engineering Laboratory, Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Moscow, Russia. E-mail: labbiocheng@cardiologu.ru
A.A. Abramov – Junior Research Scientist of Experimental Myocardial Pathology Laboratory, Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Moscow, Russia. E-mail: ferc_88@list.ru
A.V. Vavaev – Ph.D. (Biol.), Research Scientist of Biochemical Engineering Laboratory, Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Moscow, Russia. E-mail address: alex.vavaev@yandex.ru
V.L. Lakomkin – Ph.D. (Med.), Leading Research Scientist of Experimental Myocardial Pathology Laboratory, Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Moscow, Russia. E-mail: lakomkin@cardio.ru


The effects of bienzyme superoxide dismutase – chondroitin sulphate – catalase (SOD-CHS-CAT) conjugate were studied after preventive and medicative intravenous (i.v.) administration in rats with endotoxemia (due to lypopolysaccharide i.v. bolus administration). The increase of heart rate in experimental groups of rates (with SOD-CHS-CAT conjugate) became the compensatory reaction against blood pressure decrease. The SOD-CHS-CAT conjugate was active during cytokine phase of endotoxin injury and distant damage stages. The preventive and medicative action of SOD-CHS-CAT conjugate produces similar survival results (significantly 1.4 higher as compared to control) emphasizing the possibility of its therapeutic application.
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