Radiotekhnika
Publishing house Radiotekhnika

"Publishing house Radiotekhnika":
scientific and technical literature.
Books and journals of publishing houses: IPRZHR, RS-PRESS, SCIENCE-PRESS


Тел.: +7 (495) 625-9241

 

Dorsal hippocampus neuronal patterns in response to the hypothalamus motivation centers stimulation: effects of the delta-sleep inducing peptide

Keywords:

O.S. Grigorchuk, P.E. Umryukhin


Neuronal patterns in CA1 field of the dorsal hippocampus were analyzed after stimulation of motivational centers of lateral and ventromedial hypothalamus in rats with active and passive types of behavior in the open field test. A neuron may change of impulse activity pattern differently in response to the same stimulus, if the stimulus triggers a different behavior. However, various stimulus inducing similar behavioral acts, may cause similar patterns discharges the same neuron. Despite much research, the patterns of spontaneous neuronal activity organizing and distributing its inter-pulse intervals are not fully clear. The aim is to study the spatial and temporal organization of the pattern of neuronal activity of the dorsal hippocampus in the formation of positive and negative emotional and motivational excitation, as well as to test the hypothesis about the possible effects of the stress protective peptide delta sleep patterns on the performance of impulse activity. 107 neurons of CA1 field of hippocampus were registered. Preliminary injection of delta sleep-inducing peptide (DSIP) has a modulating effect on the change in the organization of the space-time characteristics of patterns of neural activity of the dorsal hippocampus. We have identified 3 types of modulation effects DSIP: Option 1 is characterized by changes in patterns of neural activity during stimulation of motivation structures in unresponsiveness neurons in this stimulation previously (10 neurons, or 9%). For the second effect is characterized by the absence of changes in neurons patterns responding to stimulation of motivation structures previously (9 or 8% of neurons). The third embodiment is characterized by changing the space and temporal characteristics of the pattern in neurons responding to stimulation of motivation zones both before and after the DSIP injection (5 or 4% of neurons). The discrepancies were found in the parameters of neuronal patterns between these groups of rats. It is shown that the stimulation of the lateral hypothalamus induces significant reorganization of the hippocampal neurons patterns, whereas ventromedial hypothalamus stimulation doesn’t. The versatile effects observed after delta sleep inducing peptide microiontophoretic application to hippocampal neurons are discussed in the article.
References:

  1. Badikov V.I. Mexanizmy' dinamicheskogo vzaimodejstviya polozhitel'ny'x i otriczatel'ny'x e'moczij v povedencheskix aktax // Avtoref. diss. dokt. med.nauk. M., 1986.
  2. Bobrovnikov L.V. Mexanizmy' motivaczionnoj determinaczii nejronnoj aktivnosti v povedenii // Psixologicheskij zhurnal. 2003. T. 24. № 4. S. 98–107.
  3. Borisyuk G.N. i dr. Modeli dinamiki nejronnoj aktivnosti pri obrabotke informaczii mozgom itogi «desyatiletiya» // Uspexi fizicheskix nauk. 2002. T. 172. № 10. S. 1189–1214.
  4. Zhuravlev B.V. Nejronny'e korrelyaty' operezhayushhix vozbuzhdenij // Sistemny'e mexanizmy' povedeniya. M., 1990. S. 171–179.
  5. Kogan A.B., Klepach G.S. O vzaimosvyazi impul'snoj aktivnosti nejronov zritel'noj kory' mozga morskoj svinki // Fiziol. Zhurn. SSSR. 1967. T. 53. № 8. S. 884.
  6. Koplik E.V. Test otkry'togo polya kak prognosticheskij kriterij ustojchivosti kry's Vistar k e'moczional'nomu stressu / E.V. Koplik [i dr.] // Zhurn. vy'sshej nervnoj deyatel'nosti im. I.P. Pavlova. 1995. T. 45. № .4. S. 775–781.
  7. Kotov A.V. Plastichnost' dominiruyushhej motivaczii // Avtoref. dokt. med.nauk. M., 1986.
  8. Kravczov A.N. Impul'snaya aktivnost' nejronov sensomotornoj kory' mozga v usloviyax podkrepleniya dominiruyushhej pishhevoj motivaczii // Integrativnaya deyatel'nost' mozga. M., 1988. S. 72–74.
  9. Meshheryakov A.F. Analiz uchastiya nejronov perifornikal'noj oblasti gipotalamusa v mexanizmax alkogol'noj motivaczii u kry's // Avtoref. diss. kand. biol. nauk. M., 1981.
  10. Shamaev N.N. Impul'snaya aktivnost' nejronov orbital'noj kory' i lateral'nogo gipotalamusa pri pishhevom povedeniiya krolika // Avtoref. diss. kand. biol. nauk. M., 1982.
  11. Shvy'rkov V.B., Aleksandrov Ju.I. Obrabotka informaczii, povedencheskij akt i korkovy'e nejrony' // DAN SSSR. 1973. T. 212. № 4. S. 1021.
  12. Shvy'rkov V.B. Nejrofiziologicheskoe izuchenie sistemny'x mexanizmov povedeniya.
  13. Bair W., Koch C. Temporal precision of spike trains in extrastriate cortex of the behaving macaque monkey // Neural computation. 1996. T. 8. № 6. S. 1185–1202.
  14. Mainen Z.F. et al. Reliability of spike timing in neocortical neurons // Science. 1995. T. 268. № 5216. S. 1503–1506.
  15. McElligott J.G. Long-term spontaneous activity of individual cerebellar neurons in the awake and unrestrained cat // In.: Brain Unit Activity DuringBehavior. 1973. Springfield. USA (Ed.: M.Ian Phillips). R. 197–223.
  16. van Steveninck R.R.R. et al. Reproducibility and variability in neural spike trains // Science. 1997. T. 275. № 5307. S. 1805–1808.

© Издательство «РАДИОТЕХНИКА», 2004-2017            Тел.: (495) 625-9241                   Designed by [SWAP]Studio