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Features element status of thyroid laboratory animals in orthotopic hyperthyroidism and hypothyroidism

Keywords:

S.V. Miroshnikov, S.V. Notova, A.B. Timasheva, O.V. Kvan


This article is devoted to the study of the elemental composition of the thyroid glands of laboratory animals in orthotopic hyperthyroidism and hypothyroidism.The study was performed on 45 male rats laboratory "Wistar", weighing 100 to 250 grams. In order to study the elemental composition as a biological substrates used samples of thyroid tissue. Using mass spectrometry, and atomic emission spectrometry with inductively coupled argon plasma content of 25 investigated the chemical elements in the thyroid gland. First obtained data on the characteristics of chemical elements in the thyroid glands of rats in experimental hyperthyroidism and hypothyroidism. It was found that rats with experimental hyperthyroidism in thyroid had a significantly higher content of Ca, Co, Ni, Hg and significantly lower Si compared with the control. In the thyroid gland hypothyroid rats were significantly higher levels of Cr and V, and significantly lower values of I and Si compared with the control. Animal experimental groups were significantly different content Ca, Mg, P, Cu, As, Se, V, Zn, Hg, Al and Sn in the thyroid gland. The dependence of the pool most of the chemical elements contained in the thyroid gland of its functions. It is suggested that the influence of thyroid status on the mineral composition of the thyroid gland to the prevailing influence of experimental hypothyroidism, mainly for the maintenance of essential and conditionally essential trace elements in the thyroid glands of laboratory animals.
References:

 

  1. E'kologicheskaya fiziologiya cheloveka. M.: Kruk. 1998. S. 416.
  2. Agadzhanyan N.A., By'kov A.T., Konovalova G.M. Adaptacziya, e'kologiya i vosstanovlenie zdorov'ya. Moskva-Krasnodar. 2003. 260 s.
  3. Agadzhanyan N.A., Smirnov V.M. Normal'naya fiziologiya. M.: MIA. 2009. S. 484 – 490.
  4. Veldanova M.V. Rol' nekotory'x strumogenny'x faktorov vneshnej sredy' v vozniknovenii zobnoj e'ndemii // Mikroe'lementy' v mediczine. 2000. T. 1. № 1. S. 17 – 25.
  5. Garkavi L.X., Kvakina E.B., Kuz'menko T.S. Antistressorny'e reakczii i aktivaczionnaya terapiya. Reakcziya aktivaczii kak put' k zdorov'yu cherez proczessy' samoorganizaczii. M.: «IMEDIS». 1998. S. 17 – 63.
  6. Denisova O.A., Baranovskaya N.V., Rixvanov L.P., Chernogoryuk G.E'., Suxix Ju.I. Mikroe'lementy' i patologiya shhitovidnoj zhelezy' v Tomskoj oblasti. Tomsk. 2011. S.17 – 28.
  7. Dzhazae'rli M.S., Davy'dov V.V. Vozrastny'e osobennosti izmeneniya konczentraczii tireoidny'x gormonov v krovi pri intensivnoj fizicheskoj nagruzke u kry's s e'ksperimental'ny'm gipotireozom. // Xar'kovskaya mediczinskaya akademiya poslediplomnogo obrazovaniya. Institut oxrany' zdorov'ya detej i podrostkov AMN Ukrainy'. 2006.
  8. Ivanov S.I., Podunova L.G., Skachkov V.B. i dr.  Opredelenie ximicheskix e'lementov v biologicheskix sredax preparatax metodami atomno-e'missionnoj spektrometrii s induktivno svyazannoj plazmoj i mass-spektrometriej // Metodicheskie ukazaniya (MUK 4.1.11482-03, MUK 4.1.1483-03). M.: FCGSE'N MZ RF, 2003.-S. 56.
  9. Miroshnikov S.V., Lebedev S.V., Barabash A.A., Timasheva A.B. Pokazateli nespeczificheskoj reakczii adaptaczii laboratorny'x zhivotny'x s razlichny'm urovnem funkczii shhitovidnoj zhelezy' // Vestnik OGU. 2011. №1 (120). S. 141 – 143.
  10. Miroshnikov S.V., Notova S.V., Kvan O.V. Osobennosti adaptaczionny'x reakczij u licz s vy'soko-i nizkonormal'ny'm urovnem tireotropnogo gormona, prozhivayushhix na territorii e'ndemichnoj po zobu // Vestnik OGU. 2011. №12. S. 293 – 297.
  11. Miroshnikov S.V., Slepy'x N.I., Miroshnikov V.I., Kuzneczov I.R. Ob''em operaczii i e'lementny'j status kak vozmozhny'e prichiny' reczidiva uzlovogo kolloidnogo e'utireoidnogo zoba // Materialy' XI S''ezda xirurgov Rossijskoj federaczii. Volgograd. 2011. S. 232 – 233.
  12. Miroshnikov S.V. Osobennosti e'lementnogo sostava shhitovidnoj zhelezy' pri uzlovom (mnogouzlovom) kolloidnom e'utireoidnom zobe // Texnologii zhivy'x sistem. 2012. № 7. S.14 – 18.
  13. Miroshnikov S.V., Notova S.V., Timasheva A.B., Man'shina L.E. Pokazateli adaptivnosti laboratorny'x zhivotny'x v usloviyax e'ksperimental'nogo izmeneniya tireoidnogo statusa // Fundamental'ny'e issledovaniya. 2012. № 10. Ch. 1. S.73 – 77.
  14. Notova S.V., Bary'sheva E.S., Lebedev S.V., Polyakova V.S., Maly'sheva N.V. Vliyanie mikroe'lementov na morfofunkczional'ny'e pokazateli shhitovidnoj zhelezy' // Vestnik OGU. 2006. № 2 (Bioe'lementologiya). S. 64 – 67.
  15. Skal'ny'j A.V. Mikroe'lementozy' cheloveka (diagnostika, lechenie). M.: Izd. KMK. 1999. 96 s.
  16. Trush V.V., Sobolev V.I. Izmenenie silovy'x xarakteristik skeletnoj my'shczy' beloj kry'sy' v proczesse uglubleniya e'ksperimental'nogo gipertireoza // Arxiv klinicheskoj i e'ksperimental'noj medicziny'. 2003. T.21. № 4. S. 144 – 149.
  17. Fadeev V.V., Mel'nichenko G.A. Gipotireoz: Rukovodstvo dlya vrachej. M.: RKI Soveropress. 2002. 216 s.

 

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