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Estimation of classifiers generalization ability in solving problem of sleep stage recognition by using heart rate variability

Keywords:

A.B. Tataraidze, L.N. Anishchenko, M.D. Alekhin


A comparative analysis of generalization ability of classifiers in the task of automated detection of REM sleep, non-REM sleep and wakefulness on the base of standard time and spectral characteristics of heart rate variability (HRV) was performed. In the study experimental database of HRV signals collected during night polysomnography monitoring for 24 male subjects aged 44,7 ± 8,1 years with sleep apnea-hypopnea index of 35,08 ± 23,8 was used. The feature space for analyzed 30-second epochs of sleep was formed applying the following standard HRV characteristics: AVNN, SDNN, rMSSD, pNN50, TP,ULF, VLF, LF, HF, LF/HF, ULF%, VLF%, LF%, HF%. Every time the calculations of feature vectors components were carried out applying 5-minute moving window with a fixed step of 30 seconds. The analyzed epoch of sleep, for which feature extraction was performed, was located in the center of the moving window. For automated detection of sleep structure on the base of time and spectral characteristics of HRV classification algorithms implemented in WEKA and Orange libraries were used. The best recognition accuracy of 83,8±0,4% and level of agreement at Cohen’s kappa value of 0,66±0,01 were achieved for the set of the following algorithms: kNN; Random Forest; Rotation Forest; AdaBoost. It should be pointed out that while estimating generalization ability of classifiers in the task of automated detection of sleep structure on the base HRV characteristics by comparing recognition accuracy with corresponding values for «gold standard» diagnostics in sleep medicine (polysomnography, PSG) the results of interpretation of PSG records by different medical experts may have significant differences. This fact may affects the quality of calculated estimates. Thus, the accuracy value of 83,8±0,4% for recognition of sleep stages should be considered as satisfactory for medical diagnostics tasks and Cohen’s kappa value of 0,66±0,01 reveals acceptable agreement of results obtained from PSG records by medical experts and automated detection of sleep structure on the base of time and spectral characteristics of HRV.
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