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Differential diagnostics of anemic syndrome in oncologic patients

Keywords:

G.N. Zubrikhina, V.N. Blindar


There were studied 250 patients: 223 oncological patients and 27 patients with iron deficit anemia (IDA). Among oncological patients light grade of anemia predominated (148 cases), moderate and heavy grade of anemia took place in 13,5% patients. The basic group of patients (150) was formed with the chronic (malignant) anemia (CMA) patients and was characterized as a normocytic normochromic anemia with high or normal level of Ferr and low or normal sTRf level and high content of RET-HE. Iron deficiency was revealed in 33% (73) patients: in 52 patients with Ferr level less than 20 ng/ml and 21 patients with Ferr level within 30-50 ng/ml which as the chronic (malignant) disease group with the iron deficiency were evaluated. The low RET-HE level obtained in 54 patients with normocytic normochromic anemia with high Ferr level could be connected with the low hemoglobin level in reticulocytes in peripheral blood and was assessed as the functional ferrum deficiecy in CMA patients. In 82,7% of patients an EPO deficiency was revealed regard to the grade of hypoxemia in CMA though in IDA EPO content corresponded to the grade of hypoxemia (92,5% cases) in anemia that could be the evidence the bone marrow erithropoietic lack.
References:
  1. Breder V.V., Gorbunova V.A., Besova N.S. Anemija pri zlokachestvennykh opukholjakh // Sovremennaja onkologija. 2002. T. 4. № 3. S. 134 – 136.
  2. Lugovskaja S.A., Kozinec G.I. Gematologija pozhilogo vozrasta. M.: «Kafedra KDL». 2010. 81 s.
  3. Alekseev N.A. Anemii. SPb.: Izd. «Gippokrat». 2004. 512 s.
  4. Gematologija / Pod red. prof. O.A. Rukovicyna. SPb. 2007. S. 106 – 121.
  5. Lis S.M., Behjjn B., Behjjts I. Prakticheskaja i laboratornaja gematologija / Pod red. prof. A.G. Ru-
    mjanceva. M.: «GEHOTAR-Media». 2009. 134 s.
  6. Pavlov A.D., Morshhakova E.F., Rumjancev A.G. EHritropoehz, ehritropoehtin, zhelezo. Molekuljarnye i klinicheskie aspekty. M.: «GEHOTAR-Media». 2011. 320 s.
  7. Blindar V.N., Zubrikhina G.N. Diagnosticheskaja znachimost opredelenija urovnja ehritropoehtina v klinicheskojj praktike (obzor literatury) // Vestnik Rossijjskogo onkologicheskogo nauchnogo centra im. N.N. Blokhina RAMN. 2007. T. 18. № 1. S. 10 – 15.
  8. Breder V.V., Gorbunova V.A., Besova N.S. Anemija v onkologicheskojj praktike. V knige «EHtjudy khimioterapii» pod red. V.A.Gorbunovojj. M.: «Litterra». 2006. S. 308 – 328.
  9. Barrett-Lee P.J., Ludwig H., Birgegard G. et al. Independent risk factors for anemia in cancer patients receiving chemotherapy: results from the European Cancer Anemia Survey // Oncology. 2006. V. 5. №1. P. 34–48.
  10. Bottini A., Berruti A., Drizzi M.P. et al.Pretreatment haemoglobin levels significantly predict the tumour response to primary chemotherapy in human breast cancer // Br. J. Cancer. 2003. V. 89. № 6. P. 977 – 982.
  11. Caro J.J., Salas M., Ward A., Goss G. Anemia as an independent prognostic factor for survival in patients with cancer: a systemic, quantitative review // Cancer. 2001. V. 91. P. 2214 – 2221.
  12. Fromer M.J. Chemotherapy-induced anemia: potencially serios but highly treatable // Oncol. Times. 2005. V. 27. № 23. P. 12 – 13.
  13. Ludwig H., Van Belle S., Barrett-Lee P.The European Cancer Anemia Survey (ECAS): a large, multinational, prospective survey defining the prevalence, incidence, and treatmernt of anemia in cancer patients // Eur. J. Cancer. 2004. V. 40. № 15. P. 2293 – 2306.
  14. Thomas C., Thomas L. Anemia of chronic disease: pathophysiology and laboratory diagnosis // Lab. Hemat.2005. V. 11.  № 1. P. 14 – 23.
  15. Pavlov A.D., Morshhakova E.F., Rumjancev A.G. Anemija pri zlokachestvennykh novoobrazovanijakh: patogenez i lechenie rekombinantnym ehritropoehtinom // Sovremennaja onkologija. 2002. T. 4. № 2. R. 50 – 54.
  16. Guseva S.A., Bebeshko V.G. EHritropoehtin. Biologicheskie svojjstva i klinicheskoe primenenie // Kiev.2005. 422 s.
  17. Betti Sisla. Rukovodstvo po laboratornojj gematologii / Pod red. A.I. Vorobeva. M.: «Prakticheskaja Medicina». 2011. S. 35.
  18. Smirnova L.A., Marcev S.P. Ferritin i ego klinicheskoe znachenie // Medicinskie novosti. 1996.
    № 7. S. 11 – 15.
  19. Blindar V.N., Zubrikhina G.N. Differencialnaja diagnostika anemijj u onkologicheskikh bolnykh // Vestnik RONC im. N.N. Blokhina RAMN. 2006. № 2. S. 19 – 21.

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