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Clinical diagnostic significance of tumor markers in liver cirrhosis

Keywords:

V.V. Bazarny, E.N. Bessonova, N.V. Garenskih, S.Y. Malareva, N.S. Beresneva


Increase of tumor markers (AFP, CA 19-9 and CA 125) levels is characteristic for liver cirrhosis, and this increase is more pronounced in decompensation stage. AFP determination can be used not only for monitoring of cirrhotic process, but also for prognosis of the speed of its progression. However, it should be mentioned that it is considered better to use a combination of tests for detection of hepatocellular carcinoma in these patients. Absence of marked deviations in CEA levels in liver cirrhosis does not allow to make definite conclusion about its value for diagnostics of hepatocellular carcinoma in patients with chronic liver diseases. In whole routine clinical application of tumor markers in patients with liver cirrhosis requires elaboration.
References:
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