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Comparative elisa study of metalloproteinases 2, 7, 9 and their type 2 tissue inhibitor in the tumors and plasma of gastric cancer

Keywords:

E.S. Gershtein, I.S. Stilidi, N.E. Kushlinskii, M.I. Davidov


Matrix metalloproteinase (MMP) 2, 7 and 9 levels were significantly increased in the tumors as compared to adjacent histologically unchanged mucosa in 80, 70 and 72% of stomach cancer patients, while the increase of type 2 tissue metalloproteinase inhibitor observed in 61% of the tumors was not statistically significant. Only MMP-7 level was increased in blood plasma of primary patients as compared to control group and was positively associated with tumor expression level of this protein. MMP-7 increase was mostly pronounced in patients with tumor invasion into lymphatic vessels. Thus, MMP-7 may be considered as a potential serologic marker of stomach cancer.
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