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Molecular biologic markers expression in chondrosarcomas, its association with clinic-morphologic characteristics and prognosis


I.V. Boulytcheva, Yu.N. Soloviev, N.E. Kushlinskii, M.D. Aliev

We retrospectively reviewed 39 patients with chondrosarcomas of different grades and 10 patients with benigh cartilaginous tumors from 2000 through 2011. The mean age of the patients was 38 years (range, 24-72 years) with a predilection for men (24/14 in chondrosarcomas). The minimum follow-up was 0,6 year. All patients underwent modern surgical treatment in N.N.Blokhin Cancer Research Centre, Moscow, Russia with incorporation of CT and MRI for details before and after the operation. To perform immunohistochemical study (MMP-1, 2, 9, TIMP-1, Col-IV, COX-2, Bcl-2, Bax) we choose 39 cases of chondrosarcomas with aggressive radiographic, and (or) morphologic behavior. Local recurrence and metastases were rare in long bones and more common in axial skeleton. The prognostic factors that determine the outcome were related to anatomic site, tumor size, and adequacy of treatment. Multidisciplinary approach in diagnoses is mandatory. Over expression of Bax, MMP-1 and MMP-9 ≥40 % is a marker for altered cell phenotype and more aggressive behavior of the tumor. Local recurrence and potential metastasis are low in the group of low grade (grade 1) chondrosarcomas. To better classify these lesions multidisciplinary approach is necessary. Radiographic criteria, morphology and immunohistochemistry help to tailor less aggressive surgical procedure without compromising the results of the treatment.

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