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Manganese sulfo-phthalocyanine as a contrast agent in magnetic resonance imaging of rat’s brain tumors


M.V. Gulyaev, G.A. Meerovich, I.G. Meerovich, V.M. Derkacheva, L.M. Borisova, O.L. Kaliya, E.A. Lukyanets, N.V. Anisimov, G.N. Vorozhtsov, Yu.A. Pirogov

After injection of contrast agents in the living organism, the effectiveness of magnetic resonance imaging (MRI) is significantly increased as a result of their accumulation in a tumor area. For today imported contrast agents (such as Magnevist, OmniScan and etc.) are usually used in MRI. This article describes the use of domestic contrast agent based on the manganese sulfo-phthalocyanine (SO3Na)2.5-PcMnOAc (Federal State Unitary Enterprise «National Research Centre «Scientific-Research Institute of Organic Intermediates and Dyes»»). Accumulated in the tumor, the contrast agent affects the T1-relaxation time of the tumor tissue, so it is detected more clearly on T1-weighted images; the brightness and contrast of the tumor are increased significantly. The discussed contrast agent was tested using modern magnetic resonance scanner Bruker BioSpec 70/30 URS (Germany) with a constant magnetic field 7 Tesla at the magnetic tomography and spectroscopy laboratory, Faculty of Basic Medicine, Lomonosov Moscow State University.
May 29, 2020

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