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Effect of hyperoxic gas environment at blood glucose animals with experimental diabetes mellitus


L.V. Shevchenko, A.I. Elfimov, V.I. Torshin, E.Y. Kalashnikova, O.N. Serova, N. Mansur

We investigated the role of the periodic effects of the environment with high content of oxygen at normal atmospheric pressure on the state of animals with experimental diabetes. Modeling insulin-dependent diabetes performed by a single injection of streptozotocin at dose of 50 mg/kg. After the injection of streptozotocin in normoxia animals increase the blood glucose and a significant decrease the body weight. Animals that were in the daily environment with increased oxygen content, body weight is not lost, glucose level in their blood was less. As a result of withdrawal hyperoxyc influences in rats again increased blood glucose and body weight began to slow. It seems promising to future study in order to correct tissue hypoxia and metabolic abnormalities that occur in experimental diabetes mellitus type 1, not only the direct effects of artificial atmosphere, but its effect in combination with pharmacological agents.
June 24, 2020
May 29, 2020

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