The aim of this research is to analyze the opportunity to use nitroalkanes for checking valid of chromatography system attached for medical preparation analysis, containing Isosorbide Mononitrate and Isosorbide Dinitrate in condition reverse-phases chromatography. Examination was directed to find nitroalkanes its chromatography characters, which was an intimate knowledge 2-isomer of Isosorbide Dinitrate (which numbered impurity in medical preparation given group). Among tested compounds for this goal was used only Nitroethane.
Using mobile phases, containing methanol, was secured better dividing isomers of Isosorbide Mononitrate. Changing correlation methanol and acetonitrile in mobile phase can be reached full coincidence of capacity factors Nitroethane and 2-isomer Isosorbide Mononitrate at chromatography.